四川精神卫生2025，Vol.38Issue(6)：486-490,5.DOI:10.11886/scjsws20250720001
不同剂量阿戈美拉汀对抑郁障碍患者肝功能的影响:一项真实世界研究
Effect of different doses of agomelatine on liver function in patients with depressive disorders:a real-world study
摘要
Abstract
Background Agomelatine,a novel antidepressant with dual efficacy in mood improvement and sleep regulation,has been widely utilized in clinical treatment of depressive disorders.The association between agomelatine and hepatic dysfunction has garnered increasing attention,yet there remains limited research on its long-term effect of liver function in real clinical scenarios.Objective To investigate the effect of different doses of agomelatine on liver function in patients with depressive disorders in real clinical scenarios,and to ascertain its safety profile and efficacy differences.Methods A retrospective study was conducted,enrolling 200 patients diagnosed with depressive disorders according to the International Classification of Diseases,tenth edition(ICD-10),who received agomelatine treatment at the Department of Psychiatry of Chaohu Hospital Affiliated to Anhui Medical University from January 2019 to December 2024.Longitudinal follow-up was performed based on real-world data.Patients were divided into a low-dose group(25 mg/d)(n=121)and a high-dose group(50 mg/d)(n=79)based on their agomelatine dosage.Follow-up assessments were conducted at baseline,the 2nd,6th,14th,and 26th weeks after treatment initiation.Liver function indicators,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBIL),were measured using a fully automated biochemical analyzer.Clinical symptoms were evaluated using the Hamilton Depression Scale-24 item(HAMD-24)and the Hamilton Anxiety Scale(HAMA).Results No statistically significant time effect,intergroup effect,or time-by-group interaction effect was observed for ALT,AST,or TBIL in either the low-dose or high-dose group(P>0.05).The time effects for both HAMD-24 and HAMA scores in the two groups were statistically significant(Ftime=430.573,395.737,P<0.01).From the end of the 2nd week of treatment onward,the scores at each follow-up time point were significantly lower than those at the baseline period(P<0.01).Conclusion Both low-dose and high-dose agomelatine may have no significant effect on liver function in patients with depressive disorders,with no difference in liver function impairment was observed between dosage groups.Low-dose and high-dose agomelatine may be equally effective in alleviating depressive and anxiety symptoms in patients with depressive disorders.关键词
阿戈美拉汀/抑郁障碍/肝功能/剂量效应/真实世界研究Key words
Agomelatine/Depressive disorder/Liver function/Dose effect/Real-world study分类
医药卫生引用本文复制引用
李军,缪世盼,王芊芊,宋苏琪,袁晓平,张凯..不同剂量阿戈美拉汀对抑郁障碍患者肝功能的影响:一项真实世界研究[J].四川精神卫生,2025,38(6):486-490,5.基金项目
安徽省委教育工委高校优秀青年人才支持计划项目(项目编号:gxyqZD2022022) （项目编号:gxyqZD2022022）
安徽省转化医学研究院科研基金重点项目(项目名称:青少年非自杀性自伤干预及机制的转化研究,项目编号:2023zhyx-B18)[Funded by the Education Work Committee of the Anhui Provincial Committee for Outstanding Young Talents in Colleges and Universities(number,gxyqZD2022022) （项目名称:青少年非自杀性自伤干预及机制的转化研究,项目编号:2023zhyx-B18）
the Key Project of Scientific Research Fund of Anhui Institute of Translational Medicine(number,2023zhyx-B18)] （number,2023zhyx-B18）
