摘要
Abstract
Background Depression in mid-to-late pregnancy has significant negative effects on pregnant women and their offspring.Previous studies have shown that pregnant women with depression in mid-to-late pregnancy exhibit lower frontal lobe activation levels,but the activation phase and its impact on depression require further investigation.Objective To analyze the functional near-infrared spectroscopy(fNIRS)features of depressed pregnant women in mid-to-late pregnancy,and to provide references for assisting in the clinical screening of depression in them.Methods A total of 40 pregnant women in mid to late pregnancy with Edinburgh Postnatal Depression Scale(EPDS)score above 11 who underwent prenatal examination at the department of obstetrics of the Third Hospital of Mianyang from September 2023 to July 2024 were included as the study group.During the same period,40 pregnant women in mid-to-late pregnancy with EPDS score below 11 who were matched with the age,family history,and past history of the study group were recruited as the control group.A self-designed questionnaire was used to collect basic information of the pregnant women.The fNIRS technique was used to measure the prefrontal and temporal lobe integral values and center of gravity values during the verbal fluency task(VFT)pregnant women in mid-to-late pregnancy.Spearman correlation analysis was conducted to examine the correlation between EPDS scores and fNIRS imaging features,as well as demographic characteristics,in mid-to-late pregnant women with depression.Multiple linear regression was used to analyze the influencing factors of depression symptoms in this population.Results Statistically significant differences were observed between the study group and the control group in terms of educational level and body mass index(BMI)(χ2/t=4.528,2.292,P<0.05).The study group demonstrated a lower prefrontal integral value and a higher prefrontal center of gravity value compared with the control group(t=-7.601,5.641,P<0.05).EPDS scores of depressed pregnant women in mid-to-late pregnancy were negatively correlated with prefrontal lobe integral value(r=-0.680,P<0.01),while positively correlated with prefrontal lobe center of gravity value and BMI(r=0.737,0.604,P<0.01).Multiple linear regression analysis showed that age(β=-0.214,P<0.01),BMI(β=0.340,P<0.01),prefrontal integral value(β=-0.351,P<0.01),and prefrontal center of gravity value(β=0.347,P<0.01)were influencing factors of depressive symptoms in pregnant women in mid-to-late pregnancy.Conclusion The prefrontal lobe activation degree of depressed pregnant women in mid-to-late pregnancy is lower than that of non-depressed pregnant women,and the activation phase is delayed.Age,prefrontal lobe integral value,prefrontal center of gravity value and BMI may be the influencing factors of depressive symptoms in pregnant women in the middle and late pregnancy.关键词
孕产妇/抑郁/功能近红外光谱成像/临床特征Key words
Pregnant and postpartum women/Depression/Functional near-infrared spectroscopy/Clinical characteristics分类
医药卫生
