药学研究2025，Vol.44Issue(12)：1161-1164,1199,5.DOI:10.13506/j.cnki.jpr.2025.12.003
五加皮化学成分及其抗炎活性
Chemical constituents and their anti-inflammatory activities of Acanthopanacis Cortex
摘要
Abstract
Objective To study the chemical constituents and anti-inflammatory activity of Acanthopanacis Cortex(root barks of Acanthopanax gracilistylus W.W.Smith).Methods Compounds were isolated by MCI column,Silica gel column,Sephadex LH-20 gel column,and high performance liquid chromatography from the 70％ethanol extract of Acanthopanacis Cortex.Using 1H-NMR,13C-NMR,MS and other spectroscopic techniques,the chemical structures of the isolated compounds was analyzed.The Griess method was used to test the anti-inflammatory activities of the isolated compounds in the mouse monocyte macrophage RAW264.7 cell release inflammatory factor model induced by lipopolysaccharide.Results 7 compounds were isolated from the ether extract of Acanthopanacis Cortex and identified as:falcarindiol(1),oplopandiol(2),3,4-dimethoxycinnamaldehyde(3),rosin(4),caffeic acid ethyl ester(5),2,3-di(3',4'-methylenedioxybenzyl)-2-butenoic acid-4-lactone(6),and threo-2,3-di(3',4'-methylenedioxybenzyl)-1,4-butanediol monoethyl ester(7).Conclusion Compounds 1～4,6～7 are obtained from this plant for the first time.The results of the anti-inflammatory activity showed that all of the compounds exhibited anti-inflammatory activities.关键词
五加皮/化学成分/木脂素/结构鉴定/抗炎活性Key words
Acanthopanacis Cortex/Chemical constituents/Lignans/Identification/Anti-inflammatory activity分类
医药卫生引用本文复制引用
张雪,许丽丽,白翠慧,牛文珊,杜玉洁,李雨薇,马烨学,郭东晓,林永强,刘青芝..五加皮化学成分及其抗炎活性[J].药学研究,2025,44(12):1161-1164,1199,5.基金项目
国家重点研发计划-中医药现代化专项(No.2023YFC3504100) （No.2023YFC3504100）
山东省重点研发计划(重大科技创新工程)项目(No.2021CXGC010511) （重大科技创新工程）
2024年山东省新旧动能转换重大产业攻关项目(重点产业攻关类)(No.35) （重点产业攻关类）
山东省技术创新项目(No.202350100442) （No.202350100442）
济南市"新高校20条"项目科研带头人工作室(No.202228096) （No.202228096）
