同济大学学报（医学版）2025，Vol.46Issue(6)：840-847,8.DOI:10.12289/j.issn.2097-4345.25182
促甲状腺激素与甲状腺功能正常人群中甲状腺结节的相关性
Association between thyroid-stimulating hormone and thyroid nodules in people with normal thyroid function
摘要
Abstract
Objective To investigate the relationship between thyroid-stimulating hormone(TSH)levels and thyroid nodules(TN)in euthyroid populations.Methods A total of 3 416 healthy adults with complete baseline data from a hospital health management center in Guangdong Province from September 2022 to September 2023 were considered as the study subjects.The logistic regression models were applied to investigate the correlations between TSH levels and their tertiles with TNs.Subgroup analyses were performed based on different stratifications.Results Compared to the non-TN group,TNs were more common in women,the age group over 41 years,and the free triiodothyronine/free thyroxine ratio(FT3/FT4)abnormal group.The levels of FT3,TSH,triglyceride(TG),uric acid(UA),and albumin(ALB)were even lower in TN group;additionally,the high density lipoprotein(HDL-C)level and systolic blood pressure(SBP)were much higher(all P＜0.05).After adjusting for confounding factors,individuals with low TSH levels had a significantly increased risk of TN detection(P＜0.001).In the TSH tertile groups,the low TSH group had a 1.980-fold higher risk of TN detection compared to the high TSH group(P＜0.001).No significant interaction of TSH with other baseline characteristics was found in the subgroup analysis of TSH and TN detected risk associations(interaction P＞0.05).Conclusion In euthyroid individuals,low serum TSH levels are associated with an increased risk of TN detection,suggesting that greater attention should be paid to thyroid health in individuals over 40 years old with low TSH levels during health examinations.关键词
甲状腺结节/促甲状腺激素/横断面研究/亚组分析Key words
thyroid nodule/thyroid-stimulating hormone/cross-sectional study/subgroup analysis分类
医药卫生引用本文复制引用
吴杰蔓,蔡梦怡,陈丽雯,梁晶晶,钟润滔,邹梦晨..促甲状腺激素与甲状腺功能正常人群中甲状腺结节的相关性[J].同济大学学报（医学版）,2025,46(6):840-847,8.基金项目
国家自然科学基金(82170840) （82170840）
广东省基础与应用基础研究基金(2021A1515220098) （2021A1515220098）
