上海针灸杂志2026，Vol.45Issue(1)：38-45,8.DOI:10.13460/j.issn.1005-0957.2026.01.0038
基于功能性近红外光谱技术探讨疏肝调神针法对广泛性焦虑障碍患者前额叶功能的影响
Exploring the effect of the Shu Gan Tiao Shen acupuncture method on prefrontal cortex function in patients with generalized anxiety disorder based on functional near-infrared spectroscopy
摘要
Abstract
Objective To investigate the regulatory effect of the Shu Gan Tiao Shen acupuncture method on prefrontal cortex function in patients with generalized anxiety disorder(GAD)using functional near-infrared spectroscopy(fNIRS).Method Forty patients with GAD were randomly divided into an acupuncture group and a medication group(20 cases each).Twenty healthy subjects were recruited as the healthy group.The acupuncture group received treatment with the Shu Gan Tiao Shen acupuncture method,while the medication group received oral escitalopram tablets.The Hamilton anxiety scale(HAMA)scores before and after treatment were compared between the two treatment groups.Changes in oxyhemoglobin(HbO2)concentration in the prefrontal cortex were analyzed between healthy control and GAD patients before treatment,acupuncture group before and after treatment,medication group before and after treatment,and acupuncture group and medication group after treatment.Result After treatment,HAMA scores significantly decreased in both the acupuncture and medication groups(P＜0.05),with the acupuncture group showing lower scores than the medication group(P＜0.05).Compared with healthy controls,GAD patients had lower HbO2 concentrations in the left dorsolateral prefrontal cortex,orbitofrontal cortex,bilateral frontopolar regions,and right ventrolateral prefrontal cortex(P＜0.05).After treatment,the medication group showed increased HbO2 concentrations in the bilateral frontopolar and orbitofrontal regions(P＜0.05),while the left dorsolateral prefrontal HbO2 concentration decreased(P＜0.05).After treatment,the acupuncture group demonstrated increased HbO2 concentrations in the bilateral frontopolar,orbitofrontal,and dorsolateral prefrontal regions(P＜0.05).Moreover,HbO2 concentrations in the dorsolateral and left ventrolateral prefrontal cortices were higher in the acupuncture group than in the medication group after treatment(P＜0.05).Conclusion The prefrontal cortex plays a crucial role in emotional regulation.The Shu Gan Tiao Shen acupuncture method may exert its therapeutic effects on GAD by modulating prefrontal cortex function.关键词
疏肝调神/广泛性焦虑障碍/近红外脑功能成像/氧合血红蛋白/额叶Key words
Shu Gan Tiao Shen/Generalized anxiety disorder/Functional near-infrared spectroscopy/Oxyhemoglobin/Prefrontal cortex分类
医药卫生引用本文复制引用
石伟静,余冬月,穆敬平,廖恒..基于功能性近红外光谱技术探讨疏肝调神针法对广泛性焦虑障碍患者前额叶功能的影响[J].上海针灸杂志,2026,45(1):38-45,8.基金项目
湖北省中医药科研立项项目(ZY2021M006,ZY2021Q015) （ZY2021M006,ZY2021Q015）
