生物加工过程2025，Vol.23Issue(6)：605-615,11.DOI:10.3969/j.issn.1672-3678.2025.06.002
谷氨酸棒杆菌木质素生物炼制与高值转化研究进展
Current advances of lignin biorefinery and valorization using Corynebacterium glutamicum
摘要
Abstract
The economically sustainable biorefinery of lignin,which is the top abundant renewable aromatic polymer in nature,is faced with a critical challenge regarding the conversion efficiency.Corynebacterium glutamicum,as a chassis for lignin valorization,exhibits distinctive advantages including its comprehensive aromatic catabolic network,weak carbon catabolite repression,and robust industrial adaptability.In this review,we firstly summarized current major industrial strategies for lignin biorefinery with C.glutamicum:pathway modification to enhance key enzyme expression and implement dynamic regulation,chassis optimization to improve monomer tolerance,and the utilization of high-cell-density fermentation coupled with in situ extraction.Additionally,we highlighted three types of high-value products synthesized according to this platform;atom-economical natural products,funneling platform chemicals,and ring-cleavage derivatives.Finally,we presented future research directions for advancing lignin biorefinery using C.glutamicum.关键词
谷氨酸棒杆菌/木质素生物炼制/芳香化合物/代谢工程/生物漏斗Key words
Corynebacterium glutamicum/lignin biorefinery/aromatic compounds/metabolic engineering/biological funnel分类
生物科学引用本文复制引用
胥健萍,赵滕菲,王倩..谷氨酸棒杆菌木质素生物炼制与高值转化研究进展[J].生物加工过程,2025,23(6):605-615,11.基金项目
国家自然学科基金(32570083) （32570083）
