生物加工过程2025，Vol.23Issue(6)：616-627,12.DOI:10.3969/j.issn.1672-3678.2025.06.003
木质素生物转化聚羟基脂肪酸酯的研究进展
Research advances in the bioconversion of lignin to polyhydroxyalkanoates
摘要
Abstract
Lignin,as the most abundant renewable aromatic resource in nature,can be utilized to produce high-value products such as biomaterials,biofuels,and biochemicals.Polyhydroxyalkanoates(PHAs)are biodegradable and biocompatible polymers synthesized by microorganisms,exhibiting broad application prospects.Microbial conversion of lignin-derived aromatics into PHAs can not only enable the valorization of lignin but also provide potential applications in industrial-scale production of PHAs.However,the recalcitrance and heterogeneity of lignin pose major challenges to its biological valorization.In this review,we summarized recent advances in PHAs biosynthesis using lignin as a feedstock,with a focus on metabolic pathways for lignin bioconversion,including key lignin depolymerization steps and intracellular PHAs synthesis routes.Furthermore,we discussed several approaches to enhance the production of PHAs through synthetic biology-guided pathway design,metabolic engineering-driven strain optimization,and AI-assisted enzyme design.In the end,we presented the important theoretical foundations and technical pathways for the high-value utilization of lignin,as well as the green and sustainable production of biodegradable plastics.关键词
木质素生物转化/木质素增值/聚羟基脂肪酸酯/合成生物学Key words
lignin bioconversion/lignin valorization/polyhydroxyalkanoates/synthetic biology分类
生物科学引用本文复制引用
宋信平,贾海媛,王辰,刘志华..木质素生物转化聚羟基脂肪酸酯的研究进展[J].生物加工过程,2025,23(6):616-627,12.基金项目
中央引导地方科技发展资金(24ZYCGSY00030) （24ZYCGSY00030）
国家重点研发计划(2023YFC3403500) （2023YFC3403500）
