天津科技大学学报2025，Vol.40Issue(6)：9-17,9.DOI:10.13364/j.issn.1672-6510.20240097
紫锥菊糖酚复合物对小鼠溃疡性结肠炎的预保护作用
Preprotective Effect of Polysaccharide-Polyphenolic Conjugate from Echinacea purpurea on Ulcerative Colitis in Mice
摘要
Abstract
Ulcerative colitis(UC)treatment drugs are expensive and often associated with varying degrees of side effects.Therefore,we extracted and isolated the polysaccharide-polyphenolic conjugate(WEPC)from the medicinal plant Echinacea purpurea,and characterized its structure using UV-vis spectroscopy,molecular weight distribution analysis,monosaccharide composition analysis and methylation analysis.We further investigated the in vivo anti-inflammatory activity of WEPC against dextran sulfate sodium(DSS)-induced UC in mice through a pre-treatment approach.The results showed that the molecular weight of WEPC was 1.103×104,and its main chain mainly composed of 4-Glcp.Moreover,WEPC could effec-tively inhibit colon length shortening of UC mice,reduce oxidative stress,and alleviate inflammatory responses associated with UC.The results of this study can provide a theoretical basis for the prevention and treatment of UC with WEPC as well as the development of related drugs.关键词
天然糖酚复合物/溃疡性结肠炎/抗炎活性Key words
natural polysaccharide-polyphenolic conjugates/ulcerative colitis/anti-inflammatory activity分类
轻工纺织引用本文复制引用
穆文倩,巩蕊琪,王雨欣,许盟盟,闫晶晶,郭庆彬..紫锥菊糖酚复合物对小鼠溃疡性结肠炎的预保护作用[J].天津科技大学学报,2025,40(6):9-17,9.基金项目
陕西省重点研发计划项目(2024SF-YBXM-158) （2024SF-YBXM-158）
