陕西科技大学学报2026，Vol.44Issue(1)：59-68,10.
姜黄素微藻载运体系的构建及评价
Construction and evaluation of curcumin-loaded microalgae delivery system
摘要
Abstract
Microalgae(MA)as a kind of self-sustaining autotrophic organism with rich nutri-tion and high photosynthetic utilization rate,has a promising development prospect in food,medicine,and genetic engineering fields.Curcumin(Cur)is a natural monomer extracted from turmeric rhizomes,which has various biological activities such as antioxidation,anti-in-flammation,anti-tumor,protection of kidneys and liver,etc.However,its solubility is ex-tremely poor and its bioavailability is relatively low.In this experiment,microalgae was used as the delivery carrier,and Curcumin microalgae delivery system(MA@Cur)was prepared by solvent evaporation method.The loading performance,release behavior,cellular uptake,gastrointestinal distribution and antioxidant activity of this system were evaluated.The re-sults showed that MA@Cur had a high loading rate and good stability,which could signifi-cantly improve the water dispersibility and intestinal fluid release degree of Cur;Cell experi-ments indicated that this system had good biocompatibility and could significantly promote the uptake of Cur by intestinal cells,effectively enhancing the antioxidant activity of Cur;The in vivo distribution experiments in mice showed that MA@Cur could prolong the retention time of active molecules in the intestinal tract.In conclusion,microalgae as the delivery carri-er of Curcumin can significantly enhance the solubility,stability and oral absorption efficiency of Curcumin,providing a reference for the efficient delivery of hydrophobic active molecules in vivo and in vitro.关键词
微藻/姜黄素/抗氧化/活性分子递送Key words
microalgae/curcumin/anti-oxidation/delivery of active ingredients分类
医药卫生引用本文复制引用
王梦琪,杨丹,周瑶,陈瑞飞,薛惠丹,刘德春,刘鸿越,秦莉..姜黄素微藻载运体系的构建及评价[J].陕西科技大学学报,2026,44(1):59-68,10.基金项目
国家自然科学基金项目(82003699) （82003699）
陕西省教育厅服务地方专项科研计划项目(24JC010) （24JC010）
陕西省科学技术协会青年人才托举计划项目(20240204) （20240204）
陕西省西安市科学技术协会青年人才托举计划项目(959202313046) （959202313046）
