心脑血管病防治2025，Vol.25Issue(11)：30-34,5.DOI:10.3969/j.issn.1009-816x.2025.11.007
运动与心肌代谢重构
Exercise and myocardial metabolic remodeling
摘要
Abstract
Cardiovascular disease is the leading cause of death worldwide,with myocardial cell metabolic dysfunction being one of its core pathological components.Under pathological conditions,such as myocardial infarction and heart failure,the heart's energy metabolism undergoes reprogramming,characterized by disrupted substrate utilization and mitochondrial dysfunction,leading to insufficient ATP and oxidative stress.Regular physical exercise has been established as a powerful metabolic intervention.It primarily protects against myocardial infarction,heart failure,and arrhythmias by activating a series of key signaling pathways that remodel myocardial metabolism in pathological states.This includes correcting the imbalance in fatty acid and glucose utilization,enhancing mitochondrial biogenesis and function,and boosting antioxidant defense capabilities.Notably,the benefits of exercise present a"double-edged sword",as its effects are dependent on the intensity and type of activity,making individualized exercise prescription crucial.Targeting these metabolic pathways regulated by exercise to develop drugs that mimic the benefits of physical activity could offer novel therapeutic strategies for cardiovascular patients who cannot tolerate exercise.关键词
心血管疾病/心肌细胞/新陈代谢/运动训练Key words
Cardiovascular diseases/Myocardial cell/Metabolism/Exercise training引用本文复制引用
周畅,韦天文,许红萍,孙玉肖,张奇..运动与心肌代谢重构[J].心脑血管病防治,2025,25(11):30-34,5.基金项目
上海市浦东新区卫生系统重点学科群建设(PWZxq-2022-02),同济大学医学院"护理学院(筹)学科建设三年行动计划"临床研究(JS2210313) （PWZxq-2022-02）
