中草药2026，Vol.57Issue(2)：405-413,9.DOI:10.7501/j.issn.0253-2670.2026.02.003
海洋真菌Talaromyces sp.13-z-02次级代谢产物的研究
Study on secondary metabolites of marine-derived fungi Talaromyces sp.13-z-02
摘要
Abstract
Objective To investigate the secondary metabolites produced by marine-derived fungi Talaromyces sp.13-z-02 and their anti-inflammatory activities were studied.Methods The isolation and purification of compounds were performed using silica gel and ODS column chromatography,semi-preparative HPLC.And their structures were elucidated by MS and NMR analyses.The isolated compounds were evaluated for their anti-inflammatory activity in zebrafish.Results One new isochromane and eleven known compounds were isolated and identified as 8-hydroxy-6-methoxy-7-methylisochromane(1)from the fermentation broth of this strain,bacillisporin B(2),macrosporusone D(3),bacillisporin F(4),1-epi-bacillisporin F(5),macrosporusone E and 1-epi-macrosporusone E(6),bacillisporin A(7),xenoclauxin(8),Sch 725680(9),aculene C(10),6-ethyl-2-hydroxy-4-methoxy-3-methylbenzaldehyde(11),6-ethyl-2,4-dihydroxy-3-methylbenzaldehyde(12).Compounds 1 and 12 significantly reduced the migration of immune cells with the same concentration of 20 μmol/L and exhibited anti-inflammatory activity.Conclusion Compound 1 is a new isochromane,designated as talaroslisochromane.Compounds 1 and 12 showed anti-inflammatory activity.关键词
海洋真菌/篮状菌13-z-02/次级代谢产物/抗炎活性/篮异色满/6-乙基-2,4-二羟基-3-甲苯甲醛基Key words
marine-derived fungi/Talaromyces sp.13-z-02/secondary metabolites/anti-inflammatory activity/talaroslisochromane/6-ethyl-2,4-dihydroxy-3-methylbenzaldehyde分类
医药卫生引用本文复制引用
许睿,孔凡栋,王聪,李培海,李子林,郑圣䶮,王见见,李佳浔,王颖,高文鹏,张洁,黄宗宏..海洋真菌Talaromyces sp.13-z-02次级代谢产物的研究[J].中草药,2026,57(2):405-413,9.基金项目
国家自然科学基金青年项目(82204276) （82204276）
广西自然科学基金项目(2025GXNSFAA069557) （2025GXNSFAA069557）
广西高等学校千名中青年骨干教师培育计划 （）
自治区级大学生创新创业训练计划(S202310608216) （S202310608216）
