中草药2026，Vol.57Issue(2)：414-424,11.DOI:10.7501/j.issn.0253-2670.2026.02.004
石岩枫的化学成分研究
Chemical constituents from Mallotus repandus
摘要
Abstract
Objective To investigate the chemical constituents of Mallotus repandus.Methods The compounds were separated and purified using a variety of chromatographic techniques,including silica gel and ODS column chromatography,as well as semi-preparative HPLC.Their structures were established by NMR and mass spectroscopy analysis.The antimicrobial activities of these isolates were evaluated by the broth microdilution method.Results Twenty-nine compounds were obtained from the dichloromethane extract of the twigs and leaves of M.repandus and identified as 3-O-cis-caffeoyl betulinic acid(1),ergosta-4,6,8(14),22-tetraen-3-one(2),β-sitostenone(3),5,8-epidioxyergosta-6,9(11),22-trien-3-ol(4),N(N'-benzoyl-S*-phenylalaninyl)-S*-phenylalaninolbenzoate(5),aurantiamide acetate(6),isoechinulin A(7),6-geranylnaringenin(8),questin(9),1,3,8-trihydroxy-6-methyl-9,10-anthracenedione(10),flavoglaucin(11),isodihydroauroglaucin(12),isoaspergin(13),5'-cis-isotetrahydroauroglaucin(14),(E)-6-hydroxy-7-(3-methyl-2-butenyl)-2-(3-oxobut-1-enyl)chroman-5-carbaldehyde(15),camellia chlorophyllide Ⅱ(16),132(R)-hydroxypheophorbide-a ethyl ester(17),ethyl pheophorbide a(18),ligulariaphytin A(19),(-)-α-tocospirone(20),α-tocospiro B(21),δ-tocopherol(22),α-tocopherolquinone(23),5-methoxypinosylvin(24),dehydroabietic acid(25),(5E,7E)-9-oxooctadeca-5,7-dienoicacid(26),(10E,12E)-ethyl-9-oxo-octadeca-10,12-dienoate(27),(10E,12Z)-9-hydroxy-10,12-octadecadienoic acid(28)and palmitic acid(29),respectively.Compound 13 has a minimum inhibitory concentration(MIC)of 128 μg/mL against Enterococcus faecalis,16 μg/mL against methicillin-resistant Staphylococcus aureus(MRSA),and 4 μg/mL against Cryptococcus neoformans.Compound 15 has an MIC of 128 μg/mL against E.faecalis,64 μg/mL against MRSA,and 8 μg/mL against C.neoformans.Conclusion Compounds 2,4,8,9,11-19,and 24-28 were reported from Euphorbiaceae plants for the first time,compounds 1,3,5,7,20,21,and 23 were reported from the genus Mallotus for the first time,and compounds 6,10,and 22 were reported from M.repandus for the first time.Compounds 13 and 15 have notable inhibitory effects on E.faecalis,MRSA,and C.neoformans.关键词
石岩枫/大戟科/抗菌活性/麦角甾-4,6,8(14),22-四烯-3-酮/金色酰胺醇酯/6-香叶草基柚皮素/大黄素-8-甲醚/异曲霉素Key words
Mallotus repandus(Willd.)Müll.Arg./Euphorbiaceae/antimicrobial activities/ergosta-4,6,8(14),22-tetraen-3-one/aurantiamide acetate/bonannione A/questin/isoaspergin分类
医药卫生引用本文复制引用
李文依,郑可欣,郑文琳,郭亚萍,周乐,贺震旦,吴炎..石岩枫的化学成分研究[J].中草药,2026,57(2):414-424,11.基金项目
国家自然科学基金资助项目(82373751) （82373751）
教育部中药现代化与创新药物研究国际合作联合实验室开放合作课题基金 （）
