中国耳鼻咽喉颅底外科杂志2025，Vol.31Issue(6)：42-46,5.DOI:10.11798/j.issn.1007-1520.202524534
诱导多能干细胞在遗传性耳聋研究中的应用
Application of induced pluripotent stem cells in the study of hereditary deafness
摘要
Abstract
Congenital sensorineural hearing loss(SNHL)is caused by genetic defects in about 50％to 60％of cases,which is often referred to as hereditary deafness.Although progress has been made in treating hereditary deafness,effective prevention and control have not yet been achieved.Induced pluripotent stem cells(iPSCs)are reprogrammed from somatic cells into pluripotent stem cells,which can then differentiate into hair cells,spiral ganglion neurons,and other inner ear sensory epithelial cells or organoids through induction methods of two-dimensional or three-dimensional in vitro.Therefore,it has received widespread attention in the field of regenerative medicine.With the continuous advancement of iPSCs technology,its application in the field of hereditary deafness research is becoming increasingly widespread.This paper reviews the the application of iPSCs in hereditary deafness research,focusing on their advantages,induction strategies,and application methods.关键词
遗传性耳聋/诱导多能干细胞/诱导分化/体外模型Key words
Hereditary deafness/Induced pluripotent stem cells/Induced differentiation/In vitro model分类
医药卫生引用本文复制引用
冯志礼,陈思源,马璐,蔡岳祥,敬前程..诱导多能干细胞在遗传性耳聋研究中的应用[J].中国耳鼻咽喉颅底外科杂志,2025,31(6):42-46,5.基金项目
长沙市自然科学基金项目(kq2208444). （kq2208444）
