中国普通外科杂志2025，Vol.34Issue(11)：2318-2325,8.DOI:10.7659/j.issn.1005-6947.250415
甲状腺癌精准诊疗现状及展望
Current status and future perspectives of precision medicine in thyroid cancer
摘要
Abstract
Thyroid cancer is the most common malignancy of the endocrine system,with a continuously rising incidence worldwide.Over the past decade,the implementation of standardized and homogeneous diagnostic and therapeutic strategies in China has led to a remarkable improvement in the 5-year survival rate of thyroid cancer patients,increasing from 67.5%in 2003 to 92.9%in 2021.Nevertheless,thyroid cancer is characterized by significant biological heterogeneity,with substantial variability in clinical presentation,disease progression,therapeutic response,and prognosis among different individuals.Consequently,the traditional treatment paradigm can no longer meet the demands of modern clinical practice.At present,the management of thyroid cancer is gradually shifting toward an individualized and precision medicine-based approach driven by molecular profiling and risk stratification.This review systematically summarizes the current status of precision diagnosis and treatment of thyroid cancer from multiple perspectives,including preoperative accurate diagnosis,risk stratification,selection of treatment modalities,individualized determination of surgical extent,and postoperative comprehensive management(such as thyroid-stimulating hormone suppression therapy,radioactive iodine therapy,and targeted therapy),aiming to provide a reference for clinical precision management of thyroid cancer.关键词
甲状腺肿瘤/分子分型/分子靶向治疗/精准医学Key words
Thyroid Neoplasms/Molecular Typing/Molecular Targeted Therapy/Precision Medicine分类
医药卫生引用本文复制引用
田文,阳泽龙..甲状腺癌精准诊疗现状及展望[J].中国普通外科杂志,2025,34(11):2318-2325,8.基金项目
北京市科技计划基金资助项目(Z141107002514102). （Z141107002514102）
