中国实用儿科杂志2025，Vol.40Issue(12)：1044-1048,5.DOI:10.19538/j.ek2025120615
儿童肺炎衣原体肺炎合并呼吸道黏液栓病例对照研究
Chlamydia pneumoniae pneumonia with mucous plug in children:a case-control study
摘要
Abstract
Objective A case-control study was conducted on the presence or absence of respiratory mucus thrombus formation in children with chlamydia pneumoniae pneumonia(CPP),and the risk factors for mucus thrombus formation were explored.Methods Children diagnosed with CPP and undergoing fiberoptic bronchoscopy at the Children's Hospital Affiliated to Zhejiang University School of Medicine from June 2024 to June 2025 were retrospectively included.They were divided into the mucus thrombus group and the non-mucus thrombus group based on whether there was mucus thrombus blocking the airway under bronchoscopy.Clinical features,laboratory data,and imaging findings were compared between the two groups.Results Of the 110 enrolled children(68 boys,42 girls;mean age 10.3 years),33(30％)had mucous plugs.Compared with the non-pluggroup,these children exhibited higher white blood cell and platelet counts,a greater incidence of hypokalemia and atelectasis,and had received macrolide therapy more frequently and for a longer duration before BAL(P＜0.05).Multivariable logistic regression identified platelet count(OR=1.006,95％CI:1.000-1.011,P=0.049)and hypokalemia(OR=7.743,95％CI:1.179-50.834,P=0.033)as independent predictors of plug formation.The Hosmer-Lemeshow test confirmed good model fit(P=0.33).Conclusion Elevated platelet count and hypokalemia are readily available early markers of impending mucous plug formation in pediatric CPP.Prompt correction of electrolyte imbalance and early BAL should be considered to prevent obstructive complications.关键词
肺炎衣原体肺炎/黏液栓/儿童Key words
Chlamydia pneumoniae pneumonia/mucous plug/child分类
医药卫生引用本文复制引用
李玲,陈文晶,林燕芬,唐兰芳..儿童肺炎衣原体肺炎合并呼吸道黏液栓病例对照研究[J].中国实用儿科杂志,2025,40(12):1044-1048,5.基金项目
浙江省中医药创新团队(11)资助项目 （11）
