中国实用妇科与产科杂志2025，Vol.41Issue(12)：1186-1190,5.DOI:10.19538/j.fk2025120109
控制性卵巢刺激对黄体功能的影响与黄体支持
Impact of controlled ovarian stimulation on luteal function and luteal phase support
摘要
Abstract
Controlled ovarian stimulation(COS),as the cornerstone of assisted reproductive technology,profoundly alters the reproductive endocrine microenvironment by promoting multifollicular development.The supraphysiological estrogen levels induced by COS suppress LH secretion through negative feedback,while the administration of GnRH analogs further disrupts pituitary function.The granulosa cell loss during oocyte retrieval and impaired steroidogenesis collectively contribute to luteal phase deficiency.Current luteal support strategies demonstrate diversified characteristics,primarily including progesterone preparations,hCG,estradiol,GnRH-a,and rLH.However,no consensus has been reached regarding optimal drug combinations and treatment timing.关键词
控制性卵巢刺激/黄体功能不全/黄体支持/辅助生殖技术Key words
controlled ovarian stimulation/luteal phase deficiency/luteal support/assisted reproductive technology分类
医药卫生引用本文复制引用
李舒怡,李艳萍..控制性卵巢刺激对黄体功能的影响与黄体支持[J].中国实用妇科与产科杂志,2025,41(12):1186-1190,5.基金项目
国家自然科学基金(82371682,82301835) National Natural Science Foundation of China(82301835,82371682) （82371682,82301835）
