中国实用内科杂志2025，Vol.45Issue(12)：1034-1042,9.DOI:10.19538/j.nk2025120106
特发性炎症性肌病患者肌炎抗体与临床表型的相关分析
Correlation analysis of myositis antibodies with clinical phenotypes in patients with idiopathic inflammatory myopathies
摘要
Abstract
Objective To investigate the distribution of myositis antibodies in patients with idiopathic inflammatory myopathies(IIM)and their correlation with clinical phenotypes.Methods A cross-sectional study was conducted to collect the clinical data of 107 patients with IIM who visited the First Affiliated Hospital of Kunming Medical University from 2018 to 2020.The distribution of myositis antibodies was analyzed,and the risk factors of IIM combined with interstitial lung disease(ILD)were evaluated.Results The top three myositis-specific antibodies(MSAs)were anti-MDA5 antibodies(27 cases,25.2％),anti-SRP antibodies(14 cases,13.1％),and anti-Jo-1 antibodies(12 cases,11.2％).The positive rates for anti-MDA5 antibodies(x2=13.433,P＜0.001),anti-EJ antibodies(x2=4.343,P=0.037),and anti-SSA/Ro-52 antibodies(x2=8.413,P=0.004)were higher in the ILD group than in the non-ILD group.Positive anti-MDA5 antibody(OR=8.675,95％CI 2.174-34.614,P=0.002)and positive anti-Ro52 antibody(OR=3.185,95％CI 1.182-8.582,P=0.022)increased the risk of ILD in patients with IIM.Compared to the negative anti-MDA5 antibody group,the positive anti-MDA5 antibody group had a higher incidence of ILD(88.9％vs.48.8％)and lower elevation of creatine kinase(CK)[72.7(35.0,111.4)U/L vs.687.1(94.0,3371.4)U/L](all P＜0.05).In the positive anti-SRP antibody group,T cells[1143.0(926.0,2343.5)cells/μL vs.779.0(587.5,1217.5)cells/μL]and B cells[525.0(179.0,1026.0)cells/μL vs.188.5(108.8,280.5)cells/μL]increased,and creatine kinase MB isoenzyme(CKMB)[300.0(29.2,641.4)U/L vs.22.3(15.3,51.4)U/L]elevated significantly,but incidence of ILD(28.6％vs.63.4％)was lower,as compared with the negative anti-SRP antibody group(All P＜0.05).Conclusion Distribution of MSAs in IIM patients is distinctive,and different MSAs subtypes are associated with characteristic clinical phenotypes.关键词
特发性炎症性肌病/肌炎抗体谱/临床表型Key words
idiopathic inflammatory myopathy/myositis antibody profile/clinical phenotype分类
医药卫生引用本文复制引用
张国芳,徐健,陶丽,李双蓉,杨一帆,刘爽,韦光伟,白茹,李姝,左卫堂..特发性炎症性肌病患者肌炎抗体与临床表型的相关分析[J].中国实用内科杂志,2025,45(12):1034-1042,9.基金项目
国家自然科学基金(32270947,81760296) （32270947,81760296）
云南省高层次卫生技术人才(领军人才)培养项目(L-2019004) （领军人才）
云南省"万人计划"名医人才专项(YNWR-MY-2018-040) （YNWR-MY-2018-040）
云南省皮肤免疫性疾病临床医学中心(YWLCYXZX2023300076,2024YNLCYXZX0019,2024YNLCYXZX0037) （YWLCYXZX2023300076,2024YNLCYXZX0019,2024YNLCYXZX0037）
风湿免疫性疾病多中心临床科研转化平台(2018ZF016) （2018ZF016）
