中国听力语言康复科学杂志2026，Vol.24Issue(1)：25-28,4.DOI:10.3969/j.issn.1672-4933.2026.01.005
听力正常小型猪皮层听觉诱发电位波形特征及应用
Cortical Auditory Evoked Potential Waveform Characteristics and Applications to Miniature pigs
摘要
Abstract
Objective To investigate the waveforms of cortical auditory evoked potential(CAEP)in miniature pigs and evaluate their utility for studying auditory cortex function and plasticity.Methods Twenty-five healthy Bama miniature pigs were screened,and those with normal hearing in both ears were enrolled.Under anesthesia,CAEP components-exogenous(P1-N1-P2)and endogenous(mismatch negativity,MMN)-were recorded using the Smart EP auditory evoked potential system.Latencies and amplitudes were analyzed.Results Of the 25 pigs,22(44 ears)exhibited ABR thresholds≤45 dB SPL.Both P1-N1-P2 complexes and MMN were reliably elicited in all 44 ears.Mean latencies were:P1 40.48±11.72ms,N1 85.20±17.42ms,P2 127.00±24.81ms,and MMN 213.27±47.86ms.Mean amplitudes were:P1-N1 2.04±1.17µV,N1-P2 1.70±0.90µV,and MMN 1.43±1.15µV.Conclusion The latency characteristics of CAEP waveforms in miniature pigs are closer to humans than those in traditional rodent models,suggesting that they may possess auditory discrimination abilities and cortical processing mechanisms similar to humans.Therefore,they can serve as a valuable model for research on auditory cortex function,development,and plasticity.关键词
小型猪/皮层听觉诱发电位/失匹配负波/人工耳蜗植入Key words
Miniature pigs/Cortical auditory evoked potential/Mismatch negativity/Cochlear implantation分类
医药卫生引用本文复制引用
唐菲,钟旻璇,杨崇灵,郭维维,刘军..听力正常小型猪皮层听觉诱发电位波形特征及应用[J].中国听力语言康复科学杂志,2026,24(1):25-28,4.基金项目
国家自然科学基金项目(82371148) （82371148）
北京市科技计划首都市民健康项目培育基金(Z131100004013019) （Z131100004013019）
解放军总医院临床科研扶持基金课题(2012FC-TSYS-4017) （2012FC-TSYS-4017）
解放军总医院科技创新基金项目(06ZY13) （06ZY13）
