中国现代医学杂志2026，Vol.36Issue(2)：1-6,6.DOI:10.3969/j.issn.1005-8982.2026.02.001
无呼吸性气流通气联合持续中低流量给氧在胸腔镜肺癌单肺通气肺保护中的效果
Effect of apneic ventilation combined with continuous low-to-moderate flow oxygen therapy on lung protection during one-lung ventilation in thoracoscopic lung cancer surgery
摘要
Abstract
Objective To analyze the effect of apneic ventilation combined with continuous low-to-moderate flow oxygen therapy on lung protection during one-lung ventilation in thoracoscopic lung cancer surgery.Methods A total of 102 patients who underwent thoracoscopic radical resection for lung cancer at Ningbo Second Hospital from January 2021 to June 2023 were prospectively included and divided into the control group and the observation group(51 cases in each group)by the random number table method.In the control group,continuous low-to-moderate flow oxygen therapy was adopted after one-lung ventilation,while in the observation group,apneic ventilation was additionally adopted.The respiratory index(RI),arterial partial pressure of carbon dioxide(PaCO2),degree of lung collapse and quality of surgical field exposure,lung tissue injury score,pulmonary cell apoptosis index,postoperative length of hospital stay,duration of postoperative mechanical ventilation and complications were compared between the two groups.Results The RI and PaCO2 at 1 minute after anesthesia induction(T0),30 minutes after one-lung ventilation(T1),and 1 hour after one-lung ventilation(T2)in the observation group and the control group were compared via the repeated measures ANOVA,which demonstrated that the RI and PaCO2 differed across the time points(F=11.265 and 13.785,both P<0.05)and between the groups(F=9.143 and 11.068,both P<0.05),and that the comparison of the change trends of RI and PaCO2 between the two groups showed statistically significant differences(F=10.372 and 12.412,both P<0.05).The overall effective rate of the observation group was higher than that of the control group(P<0.05).The lung tissue injury score and the pulmonary cell apoptosis index in the observation group were both lower than those in the control group(P<0.05).The duration of postoperative mechanical ventilation and postoperative length of hospital stay in the observation group were both shorter than those in the control group(P<0.05).There was no statistically significant difference in the overall incidence of complications between the control group and the observation group(P>0.05).Conclusion Apneic ventilation combined with continuous low-to-moderate flow oxygen therapy exhibits a definite effect on lung protection during one-lung ventilation in thoracoscopic lung cancer surgery.It reduces lung tissue injury,improves RI and PaCO2,promotes postoperative recovery,and is safe and reliable.关键词
肺癌/胸腔镜/单肺通气/无呼吸性气流通气/持续中低流量给氧/肺保护Key words
lung cancer/thoracoscopy/one-lung ventilation/apneic ventilation/continuous low-to-moderate flow oxygen therapy/lung protection分类
医药卫生引用本文复制引用
方博渊,杨明磊,汪炎磊..无呼吸性气流通气联合持续中低流量给氧在胸腔镜肺癌单肺通气肺保护中的效果[J].中国现代医学杂志,2026,36(2):1-6,6.基金项目
浙江省医药卫生科技计划项目(No:2022482758) （No:2022482758）
宁波市医疗卫生高端团队重大攻坚项目(No:2022030208) （No:2022030208）
