中国现代医学杂志2026，Vol.36Issue(2)：49-54,6.DOI:10.3969/j.issn.1005-8982.2026.02.008
吡格列酮二甲双胍片联合去氧孕烯炔雌醇片治疗多囊卵巢综合征合并不孕患者的疗效观察
Efficacy of pioglitazone/metformin tablets combined with desogestrel/ethinyl estradiol tablets in treating infertility in patients with polycystic ovary syndrome
摘要
Abstract
Objective To observe the effect of pioglitazone/metformin tablets combined with desogestrel/ethinyl estradiol tablets in treating infertility in patients with polycystic ovary syndrome(PCOS).Methods The medical records of 83 PCOS patients with infertility treated at Xi'an People's Hospital from May 2022 to October 2024 were retrospectively analyzed and divided into the observation group(42 cases treated with pioglitazone/metformin tablets and desogestrel/ethinyl estradiol tablets)and the control group(41 cases treated with desogestrel/ethinyl estradiol tablets)based on the treatment regimens.Both groups were treated for 3 months.Levels of sex hormones[estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)]and serum progesterone(SP),clinical efficacy,ovarian volume,follicle count,serum indicators[soluble receptor for advanced glycation end products(sRAGE),total antioxidant capacity(T-AOC),tumor necrosis factor-α(TNF-α),and oxidative stress index(OSI)],and adverse reactions were compared between the two groups.Results After treatment,levels of E2,FSH,and SP in the observation group were significantly higher than those in the control group(all P<0.05),whereas LH levels were significantly lower(P<0.05).The changes in E2,LH,FSH,and SP levels before and after treatment were all significantly greater in the observation group than in the control group(all P<0.05).The overall clinical efficacy rate was significantly higher in the observation group compared with the control group(P<0.05).After treatment,ovarian volume and follicle count were significantly lower in the observation group than in the control group(both P<0.05),and the changes in ovarian volume and follicle count before and after treatment were significantly greater in the observation group(both P<0.05).Post-treatment levels of sRAGE,T-AOC,levels of TNF-α,and OSI were all significantly lower in the observation group than in the control group(all P<0.05).Moreover,the changes in levels of sRAGE,T-AOC,levels of TNF-α,and OSI before and after treatment were significantly greater in the observation group(all P<0.05).There was no statistically significant difference in the overall incidence of adverse events between the two groups(P>0.05).Conclusion Pioglitazone/metformin tablets combined with desogestrel/ethinyl estradiol tablets are effective in the treatment of PCOS patients with infertility.This combination regulates the levels of sex hormones and serum TOS and OSI,improves clinical symptoms,mitigates inflammation,and is safe and reliable.关键词
多囊卵巢综合征/吡格列酮二甲双胍片/去氧孕烯炔雌醇片/临床疗效/不孕/不良反应Key words
polycystic ovary syndrome/pioglitazone/metformin tablets/desogestrel/ethinyl estradiol tablets/clinical effect/infertility/adverse reaction分类
医药卫生引用本文复制引用
乔顺,任丹玉..吡格列酮二甲双胍片联合去氧孕烯炔雌醇片治疗多囊卵巢综合征合并不孕患者的疗效观察[J].中国现代医学杂志,2026,36(2):49-54,6.基金项目
陕西省自然科学基金(No:2022JM-484) （No:2022JM-484）
