中国现代医学杂志2026，Vol.36Issue(2)：61-66,6.DOI:10.3969/j.issn.1005-8982.2026.02.010
结直肠癌伴肝转移患者同期根治性切除术后复发与肿瘤生物学特征的相关性研究
Correlation between tumor biological characteristics and postoperative recurrence in patients with colorectal cancer and liver metastases undergoing synchronous radical resection
摘要
Abstract
Objective To explore the correlation between tumor biological characteristics and postoperative recurrence in patients with colorectal cancer and liver metastases undergoing synchronous radical resection.Methods A total of 108 patients with colorectal cancer and liver metastases who were treated at our hospital from January 2022 to January 2024 were selected.All patients underwent laparoscopic radical resection of colorectal cancer and extensive hepatic segmentectomy or hepatectomy.The recurrence status of patients was recorded one year after surgery,and they were divided into a recurrence group and a non-recurrence group.The preoperative tumor biological characteristics and tumor marker levels of the two groups were compared,and the risk factors for postoperative recurrence in patients with colorectal cancer and liver metastases were analyzed.Results Comparisons of baseline characteristics,including sex distribution,age,body mass index,family history of colorectal cancer,and liver function grading,showed no significant differences between the two groups(P>0.05).Similarly,no significant differences were observed in primary tumor location,pathological type,degree of differentiation,or T stage(P>0.05).However,the recurrence group had a higher proportion of N2 stage disease compared with the non-recurrence group(P<0.05).Patients in the recurrence group also exhibited higher rates of bilateral liver metastases,number of metastatic lesions>1,synchronous liver metastases,and larger maximum diameter of metastases than those in the non-recurrence group(P<0.05).No significant differences were found between the two groups in serum levels of CEA,CA19-9,and AFP,or the proportion of p53-positive cases(P>0.05).Conversely,the proportion of nm23-positive cases was lower in the recurrence group than in the non-recurrence group(P<0.05).Multivariable logistic regression analysis identified N2 stage[(O^R)=4.509(95%CI:2.024,10.044)],bilateral liver metastases[(O^R)=4.354(95%CI:1.954,9.699)],greater number of metastatic lesions[(O^R)=4.076(95%CI:1.829,9.079)],synchronous liver metastases[(O^R)=3.725(95%CI:1.672,8.298)],larger maximum diameter of metastases[(O^R)=4.884(95%CI:2.192,10.881)],and nm23 positivity[(O^R)=5.018(95%CI:2.252,11.178)]as independent risk factors for postoperative recurrence in patients with colorectal cancer and liver metastases(all P<0.05).Conclusion N stage,bilateral liver metastases,number of metastatic lesions,synchronous liver metastases,maximum diameter of metastases,and nm23 positivity are associated with postoperative recurrence in patients with colorectal cancer and liver metastases.关键词
结直肠癌/肝转移/根治性切除术/复发/肿瘤生物学特征Key words
colorectal cancer/liver metastasis/radical resection/recurrence/tumor biological characteristics分类
医药卫生引用本文复制引用
李光平,杨涛,孙宏治..结直肠癌伴肝转移患者同期根治性切除术后复发与肿瘤生物学特征的相关性研究[J].中国现代医学杂志,2026,36(2):61-66,6.基金项目
辽宁省科技计划项目(No:2023JH2/101700149) （No:2023JH2/101700149）
辽宁省教育厅科学技术研究项目(No:JYTZD2020005) （No:JYTZD2020005）
