中国畜牧兽医2026，Vol.53Issue(1)：15-26,12.DOI:10.16431/j.cnki.1671-7236.2026.01.002
单细胞测序技术在畜禽遗传育种中的应用研究进展
Research Progress on the Application of Single-cell Sequencing Technology in Livestock and Poultry Genetic Breeding
摘要
Abstract
Cells are the fundamental units that make up living organisms,possessing unique developmental trajectories and molecular features.Single cell sequencing technology,as an efficient method for analyzing genetic information at the cellular level,can sequence the genome,transcriptome,proteome,metabolome,and epigenetics,and support integrated analysis strategies such as multi-omics sequencing to accurately capture the molecular characteristics of individual cells.This technology breaks through the limitations of traditional population cell research,and has become a powerful tool for analyzing the molecular regulatory mechanisms and cell fate transition trajectories of animal cells,providing a new perspective for animal genetics breeding.The artical focuses on five single-cell sequencing technologies—Single-cell RNA sequencing,single-cell DNA sequencing,single-cell epigenome sequencing,single-cell proteomics sequencing,and single-cell metabolomics sequencing,systematically elaborates on the developmental history and underlying principles,and discusses in depth the application cases of single-cell sequencing technology in livestock and poultry genetic breeding,aiming to provide a theoretical reference for subsequent research in this field.关键词
单细胞测序/多组学/畜禽遗传育种Key words
single cell sequencing/multi-omics/livestock and poultry genetic breeding分类
农业科技引用本文复制引用
柴圆,于国杰,林靖凯,张文广,包成林,张玲艳,宫淑艳,齐澈力木格,鲍艳春,朱蒙,曹赛,李建功..单细胞测序技术在畜禽遗传育种中的应用研究进展[J].中国畜牧兽医,2026,53(1):15-26,12.基金项目
内蒙古自治区自然科学基金项目(2023QN03026) （2023QN03026）
兴安职业技术学院青年科技英才支持项目(2023530) （2023530）
国家自然科学基金项目(32460817) （32460817）
内蒙古农业大学双一流建设资金(CG202423、CG202410) （CG202423、CG202410）
内蒙古自治区自然科学基金项目(2021ZD05) （2021ZD05）
