中国药理学通报2026，Vol.42Issue(1)：1-5,5.DOI:10.12360/CPB202505072
脏器纤维化疾病与原颗粒蛋白的作用机制及研究进展
Mechanisms and research progress of progranulin in organ fibrotic diseases
摘要
Abstract
Fibrotic diseases are the common pathological out-come of various chronic tissue injuries,characterized by exces-sive deposition of extracellular matrix(ECM)and organ dys-function.The pathogenesis is complex,and effective treatment strategies are lacking.Progranulin(PGRN),a multifunctional secretory glycoprotein,exhibits a complex and organ-specific bi-directional regulatory effect in the process of fibrosis.This re-view systematically elaborates on the role of PGRN in various fi-brotic diseases and the research progress.In the progression of pulmonary fibrosis and liver fibrosis,PGRN primarily exerts an antifibrotic effect by inhibiting key signaling pathways such as TGF-β/Smad,MAPK(ERK/JNK/p38),and NF-κB,reducing the release of inflammatory factors,inhibiting fibroblast activa-tion,and collagen deposition.PGRN shows a pro-fibrotic ef-fect,possibly promoting fibrosis through the activation of the TGF-β/Smad pathway.Despite the significant potential of PGRN as an antifibrotic therapeutic target,the differences in its effects on fibrosis in different organs and the complex regulatory networks require further clarification.Future research should focus on elucidating the tissue-specific mechanisms of PGRN,developing targeted therapies based on PGRN or its derivatives,and validating its value as a biomarker in clinical diagnosis,prognosis evaluation,and treatment monitoring.This would pro-vide new ideas for overcoming the therapeutic bottleneck in fi-brotic diseases.关键词
原颗粒蛋白/纤维化疾病/肺纤维化/肝纤维化/TGF-β/Smad信号通路/MAPK信号通路/NF-κB信号通路Key words
progranulin(PGRN)/fibrotic diseases/pulmo-nary fibrosis/hepatic fibrosis/TGF-β/Smad signaling pathway/MAPK signaling pathway/NF-κB signaling pathway分类
医药卫生引用本文复制引用
哈庆旭,程明涵,董红亮,高建..脏器纤维化疾病与原颗粒蛋白的作用机制及研究进展[J].中国药理学通报,2026,42(1):1-5,5.基金项目
国家自然科学基金资助项目(No 81973637,82373933) （No 81973637,82373933）
