中国药理学通报2026，Vol.42Issue(1)：6-11,6.DOI:10.12360/CPB202506051
阅读蛋白IGF2BPs家族在心血管疾病发生发展中的作用和机制
Role and mechanism of m6A reader IGF2BPs family in occurrence and development of cardiovascular disease
摘要
Abstract
N6-methyladenosine(m6A)is the most abundant in-ternal modification in eukaryotic RNA and is involved in various physiological and pathological processes.The m6A methylation modification is jointly participated by methyltransferases(writ-ers),demethylases(erasers),and reader proteins.Among them,the IGF2BPs family of reader proteins,including IGF2BP1,IGF2BP2,and IGF2BP3,play extensive roles in regulating RNA fate,especially in cardiovascular diseases.This article summarizes the structure,function,and role and mechanism of the IGF2BPs family in cardiovascular diseases,and introduces the research progress of small molecule inhibi-tors targeting them,providing a new perspective for the regula-tion of m6A in cardiovascular diseases.关键词
m6A修饰/阅读蛋白/IGF2BPs/心血管疾病/小分子抑制剂/作用机制Key words
m6A modification/reader proteins/IGF2BPs/car-diovascular diseases/small molecule inhibitors/mechanism分类
医药卫生引用本文复制引用
周月姣,王智墨,于庆文,王琮,王沛,张莉蓉,韩圣娜..阅读蛋白IGF2BPs家族在心血管疾病发生发展中的作用和机制[J].中国药理学通报,2026,42(1):6-11,6.基金项目
国家自然科学基金面上项目(No 82270287) （No 82270287）
