中国药理学通报2026，Vol.42Issue(1)：21-26,6.DOI:10.12360/CPB202506100
中药调控心律失常相关信号通路研究进展
Research progress on regulation of signaling pathways related to arrhythmia by traditional Chinese medicine
摘要
Abstract
Arrhythmia is one of the common public health prob-lems in the world,posing a great threat to human health and being a major challenge in the medical field.More and more studies have found that traditional Chinese medicine regulates ion channels,improves electrical conduction,inhibits cardio-myocyte apoptosis and autophagy,and reduces oxidative stress and inflammation by modulating signaling pathways such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/Akt),calcium/calmodulin-dependent protein kinase II(CaMKII),nuclear factor red factor 2-related factor 2(NRF2),and nuclear factor κB(NF-κB),thus improving cardiac function and slowing down disease progression.It reduces oxidative stress and inflammation,thus improving cardiac function,slow-ing down disease progression and preventing arrhythmia in mul-tiple ways.Therefore,this article systematically summarizes the mechanisms by which traditional Chinese medicine inter-venes in related signaling pathways to treat arrhythmia,laying a theoretical foundation for its large-scale clinical application and new drug development.关键词
心律失常/中医药/信号通路/作用机制/研究进展Key words
arrhythmia/traditional Chinese medicine/signal-ing pathway/mechanism of action/research progress分类
医药卫生引用本文复制引用
王选阳,朱明军,李彬,于瑞,王建茹,孙雨蝶,丁浩,张文评,高原..中药调控心律失常相关信号通路研究进展[J].中国药理学通报,2026,42(1):21-26,6.基金项目
国家自然科学基金重点项目(No 82030120) （No 82030120）
国家自然科学基金青年基金项目(No 81503435) （No 81503435）
河南省中医药科学研究专项课题(No 2022ZY2009) （No 2022ZY2009）
河南省国际科技合作项目(No 252102521036) （No 252102521036）
河南省重点研发与推广专项(科技攻关)项目(No 242102310554,242102310527,252102310470) （科技攻关）
