中国药理学通报2026，Vol.42Issue(1)：26-30,5.DOI:10.12360/CPB202508024
线粒体功能障碍与抑郁症的分子机制研究进展
Molecular mechanisms linking mitochondrial dysfunction to depression:recent progress
摘要
Abstract
Depression,a prevalent mental disorder,remains in-completely understood in terms of its pathogenesis.Growing evi-dence suggests that mitochondrial dysfunction plays a critical role in the pathophysiology of depression.As the primary en-ergy producers of cells,dysfunctional mitochondria exhibit im-paired energy metabolism,mitochondrial autophagy imbalance,and elevated oxidative stress,contributing to neuronal dysfunc-tion and exacerbating depressive symptoms.Investigating the molecular regulatory mechanisms underlying mitochondrial dys-function in depression not only helps to clarify the pathogenesis of depression but also provides a theoretical basis for the devel-opment of new antidepressant drugs targeting mitochondria.This review systematically examines the link between mitochon-drial dysfunction and depression,and explores its potential mo-lecular mechanisms,offering new perspectives for diagnostic and therapeutic strategies.关键词
抑郁症/线粒体/融合与分裂/能量代谢/线粒体自噬/氧化应激Key words
depression/mitochondria/fusion and fission/en-ergy metabolism/mitochondrial autophagy/oxidative stress分类
医药卫生引用本文复制引用
邢赞,王真真,陈乃宏..线粒体功能障碍与抑郁症的分子机制研究进展[J].中国药理学通报,2026,42(1):26-30,5.基金项目
国家自然科学基金资助项目(No 82130109,82473908) （No 82130109,82473908）
