摘要
Abstract
Objective:To investigate the changes in echocardiographic parameters and serum Adropin levels in patients with dilated cardiomyopathy(DCM)before and after treatment,and analyze their correlation with treatment efficacy and their evaluation value.Methods:A total of 96 patients with DCM who were treated in our hospital from May 2022 to May 2024 were selected retrospectively.All patients were given conventional treatment,and they were divided into an effective group of 70 patients and an ineffective group of 26 patients based on the therapeutic effect after 3 months of treatment.The clinical data and echocardiographic parameters[left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),left atrial diameter(LAD)],serum Adropin levels were compared between the two groups.The impact of echocardiographic parameters and serum Adropin levels on the therapeutic effect was analyzed,and their correlation with the therapeutic effect was analyzed.The evaluation value of echocardiographic parameters and serum Adropin on the therapeutic effect was analyzed.Results:After treatment,the LVESV,LVEDV,LAD,and serum Adropin levels in the effective group were lower than those before treatment and lower than those in the ineffective group(P＜0.05);multivariate Logistic regression analysis showed that after adjusting for age,disease duration,and NYHA functional classification,LVESV,LVEDV,LAD,and Adropin were still associated with treatment efficacy(P＜0.05).Partial correlation analysis showed that LVESV,LVEDV,LAD,and Adropin were negatively correlated with treatment efficacy(P＜0.05).After one month of treatment,the AUC values for the individu-al and combined assessment of LVESV,LVEDV,LAD,serum Adropin,and the therapeutic effect were 0.769,0.757,0.790,0.754,and 0.916,respectively.The AUC value for the combined assessment was greater than that for each individual indicator(P＜0.05).Conclusion:LVESV,LVEDV,LAD,and serum Adropin levels are factors associated with the therapeutic efficacy in patients with DCM,and are negatively correlated with the therapeutic efficacy.Combined detection of their levels has certain evaluation value for the therapeu-tic efficacy.关键词
扩张型心肌病/超声心动图参数/能量平衡相关蛋白/相关性分析/评估价值Key words
Dilated cardiomyopathy/Echocardiographic parameters/Energy balance-related proteins/Correlation analysis/Evalua-tion value分类
医药卫生
