中国药物评价2025，Vol.42Issue(6)：453-459,7.
中药提取物在皮肤色素沉着治疗中的研究进展
Research Advances of Traditional Chinese Medicine Extracts in the Treatment of Skin Pigmentation
周津羽 1刘奕娴 1李珍玉 1黄冬强1
作者信息
- 1. 海南省药品和医疗器械审评服务中心,海南海口 570216
- 折叠
摘要
Abstract
Skin pigmentation is a prevalent dermatological condition,the underlying mechanism of which is the aberrant activation of melanin synthesis and signalling pathways.The most effective strategies for intervening in abnormal pigment deposition involve targeted in-hibition of the catalytic activity of key rate-limiting enzymes,such as tyrosinase,and effective blockade of the transduction of pro-melano-tic signalling pathways,such as α-MSH-MC1R and SCF-c-Kit.Research has indicated that Traditional Chinese Medicines(TCM)are a-bundant in bioactive substances and possess considerable potential in modulating pigmentation.Representative extracts,including paeoni-florin in Paeonia lactiflora and glycyrrhizin in Glycyrrhiza and ferulic acid in Angelica sinensis,have been shown to play important roles in inhibiting tyrosinase activity and regulating melanocyte metabolism.This paper systematically summarises the mechanism of action of pig-mentation,as well as the progress of research on the active constituents of traditional Chinese medicine extracts,thereby providing a theo-retical foundation and potential avenues for future research and application in the field of TCM whitening cosmetic raw materials.关键词
中药提取物/色素沉着/研究进展/中药治疗Key words
TCM extracts/Pigmentation/Research progress/Chinese herbal medicine treatment分类
医药卫生引用本文复制引用
周津羽,刘奕娴,李珍玉,黄冬强..中药提取物在皮肤色素沉着治疗中的研究进展[J].中国药物评价,2025,42(6):453-459,7.
