中国药物评价2025，Vol.42Issue(6)：460-463,4.
中药材抑菌活性研究及发展探析
Research and Development Analysis on the Antibacterial Activity of Chinese Medicinal Materials
摘要
Abstract
Through a study on the microbial limit test method suitability testing of traditional Chinese medicine(TCM)preparations with effects such as promoting blood circulation and resolving blood stasis,nourishing blood and replenishing qi,and dredging meridians and activating collaterals—used in treating cardiovascular diseases like coronary heart disease and hyperlipidemia—it was discovered that some preparations exhibit strong antimicrobial activity.Notably,TCM formulations with heat-clearing and detoxifying properties commonly contain herbs such as Lonicerae Japonicae Flos,Forsythiae Fructus,Scutellariae Radix,TaraxaciHerba,Isatidis Folium,and Isatidis Ra-dix which are widely recognized for their significant antibacterial and anti-inflammatory effects.In this study,16 locally sourced TCM preparations with the aforementioned cardiovascular therapeutic effects were screened for microbial limit testing,all demonstrating inhibito-ry activity against microorganisms.By analyzing the herbal compositions of these preparations and reviewing extensive literature,20 herbal components were identified to possess antibacterial properties,with certain constituents exhibiting particularly potent bacteriostatic or bac-tericidal effects.These findings highlight that the antimicrobial activity of TCM preparations is primarily attributed to their bioactive herbal constituents.This research provides valuable insights for the development,formulation,and quality control of pharmaceutical products.关键词
中药制剂/微生物限度检查方法适用性试验/活血化瘀/中药材/抑菌活性Key words
Traditional Chinese medicine preparations/Microbial limit test method validation/Activating blood circulation and resol-ving stasis/Herbal materials/Antimicrobial activity分类
医药卫生引用本文复制引用
杨铭,昝珂,赵磊..中药材抑菌活性研究及发展探析[J].中国药物评价,2025,42(6):460-463,4.基金项目
济宁市重点研发计划软科学项目(2024JNZC119) （2024JNZC119）
