中国医药科学2025，Vol.15Issue(24)：74-78,5.DOI:10.20116/j.issn2095-0616.2025.24.15
子痫前期孕妇应用血栓弹力图联合尿蛋白定量检测的临床意义
Clinical significance of thromboelastography combined with urine protein quantification in pregnant women with preeclampsia
摘要
Abstract
Objective To study the clinical significance of thromboelastography(TEG)examination and urine protein quantification in pregnant women with preeclampsia(PE).Methods A total of 150 pregnant women with PE admitted to the Department of Obstetrics,the First Hospital of Sanming,Fujian Province from December 2023 to December 2024 were selected as the research subjects.All pregnant women underwent TEG examination and urine protein quantification.According to the severity of PE in pregnant women,they were divided into the mild PE group(n=87)and the severe PE group(n=63).The results of TEG and urine protein quantification of pregnant women were collected and the correlation between them was analyzed.Follow-up was carried out until delivery.According to the pregnancy outcomes,the pregnant women were divided into the normal outcome group(n=112)and the adverse outcome group(n=38).The influence of TEG combined with urine protein quantification in predicting adverse pregnancy outcomes in pregnant women with PE was analyzed.Results There were statistically significant differences in K time,alpha angle,24-hour urinary protein quantification,CI,R time,and MA values between the mild PE group and the severe PE group(P<0.05).The 24-hour urine protein quantification was negatively correlated with the TEG parameter R time and positively correlated with the MA value(both P<0.001).In terms of different pregnancy outcomes of pregnant women with PE,the R time in the normal outcome group was longer than that in the adverse outcome group,and the MA value,CI index,and 24-hour urine protein quantification were significantly lower than those in in the adverse outcome group(P<0.001).After analysis,24-hour urine protein quantification and TEG R-time,MA value,and CI index have certain predictive value for adverse pregnancy outcomes in PE pregnant women.The combination of TEG examination and 24-hour urine protein quantification detection can improve the predictive value for adverse outcomes(AUC=0.990,P<0.001).Conclusion TEG and urinary protein quantification testing in pregnant women with PE can help predict adverse pregnancy outcomes,guide clinical physicians to terminate pregnancy at appropriate times,and improve maternal and neonatal outcomes.关键词
子痫前期/血栓弹力图/尿蛋白/凝血功能/不良妊娠结局Key words
Preeclampsia/Thromboelastography/Urinary protein/Coagulation function/Adverse pregnancy outcomes分类
医药卫生引用本文复制引用
马菲菲,吴秀珍,李晨,林拱冰..子痫前期孕妇应用血栓弹力图联合尿蛋白定量检测的临床意义[J].中国医药科学,2025,15(24):74-78,5.基金项目
福建省自然科学基金资助项目(2023J01150) （2023J01150）
福建省三明市科技计划项目(2021-S-5). （2021-S-5）
