中华临床免疫和变态反应杂志2025，Vol.19Issue(6)：455-461,7.DOI:10.3969∕j.issn.1673-8705.2025.06.010
浆细胞样树突状细胞在过敏性疾病中的作用及机制
The role and mechanism of plasmacytoid dendritic cells in allergic diseases
朱军容 1王上上 2李巍 2徐金华2
作者信息
- 1. 430000 武汉,湖北省中医院(湖北中医药大学附属医院,湖北省中医药研究院,湖北时珍实验室)皮肤病与性病科
- 2. 200040 上海,复旦大学附属华山医院皮肤病与性病科
- 折叠
摘要
Abstract
The allergic process is a pathological process that spans the entire lifecycle,typically mani-festing as a sequential progression from atopic dermatitis(AD)in infancy to food allergies,asthma,and al-lergic rhinitis(AR).Increasing research indicates that dendritic cells(DCs)play a crucial role in allergic inflammation.Among them,conventional dendritic cells(cDCs)induce Th2-type immune responses,promo-ting the onset and progression of allergic diseases,while plasmacytoid dendritic cells(pDCs)exhibit unique immune regulatory potential,playing a key role in both pro-inflammatory and immune homeostasis maintenance.However,how the immune regulatory mechanisms mediated by pDCs affect the staged evolution of the allergic process remains a core scientific issue that needs to be addressed urgently in this field.This article aims to review the potential functional heterogeneity of pDCs in different stages of allergic reactions,providing a theoretical basis for further understanding of the immune regulatory roles of DC subsets in allergic diseases.关键词
浆细胞样树突状细胞/特应性皮炎/过敏性鼻炎/过敏性哮喘Key words
Plasmacytoid dendritic cells/atopic dermatitis/allergic rhinitis/allergic asthma引用本文复制引用
朱军容,王上上,李巍,徐金华..浆细胞样树突状细胞在过敏性疾病中的作用及机制[J].中华临床免疫和变态反应杂志,2025,19(6):455-461,7.
