中国猪业2025，Vol.20Issue(6)：12-24,13.DOI:10.16174/j.issn.1673-4645.2025.06.002
MSTN基因敲除对猪产肉性状与脂肪沉积的影响及其分子机制
MSTN knockout in pigs:impacts on meat production traits,fat deposition,and molecular mechanisms
摘要
Abstract
As a member of the transforming growth factor-β(TGF-β)superfamily,myostatin(MSTN)plays a critical role in regulating skeletal muscle development and lipid deposition.Due to the rapid advancement of gene editing technology and the need for high pro-duction performance in practical applications,a growing number of studies have carried out MSTN knockout in different pig breeds.This review summarized the important function of MSTN in breeding and systematically analyzed the phenotypic outcomes of MSTN-knockout pigs,including muscle development,carcass traits,fat deposition,and meat quality.Overall,MSTN-knockout pigs generally exhibit higher lean meat yield,lower fat content,improved tenderness,and enhanced nutritional profiles-particularly in terms of polyunsaturat-ed fatty acids and amino acids.At the molecular level,MSTN knockout activates the PI3K/AKT/mTOR pathway to promote protein syn-thesis and modulates lipid metabolism via the ERK1/2 signaling pathway,thereby significantly improving meat quality and metabolic characteristics.In conclusion,obtaining a deeper understanding of the role and mechanisms of MSTN is crucial for animal breeding and provides promising strategies to enhance meat production in livestock.关键词
猪/MSTN/基因敲除/肉质性状/脂肪沉积/分子调控Key words
pig/MSTN/gene knockout/meat quality/fat deposition/molecular regulatory分类
农业科技引用本文复制引用
菅传辉,李亚林,王琦涵,王讯,金龙,龙科任..MSTN基因敲除对猪产肉性状与脂肪沉积的影响及其分子机制[J].中国猪业,2025,20(6):12-24,13.基金项目
四川省"十四五"川猪重大科技专项"川猪育种新材料创制与新品种培育" （）
