转化医学杂志2026，Vol.15Issue(1)：1-5,5.DOI:10.3639/j.issn.2095-3097.2026.01.001
脓毒症患者TLR9、GDF15表达水平及与急性肾损伤发生的关系
Expression Levels of Serum TLR9 and GDF15 in Patients with Sepsis and Their Relationship with the Occurrence of Acute Kidney Injury
摘要
Abstract
Objective To investigate the relationship between the levels of Toll-like receptor 9(TLR9)and growth differentiation factor 15(GDF15)and the occurrence of acute kidney injury(AKI)in patients with sepsis.Methods A total of 106 patients with sepsis admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January 2020 to June 2024 were retrospectively selected as the control group,and 160 patients with sepsis-associated AKI during the same period were selected as the study group.The clinical data and expression levels of TLR9 and GDF15 were compared between the two groups.Spearman correlation analysis was used to explore the correlation between TLR9 and GDF15 expression levels and the occurrence of AKI in sepsis patients.Receiver operating characteristic(ROC)curve analysis was applied to evaluate the predictive value of TLR9 and GDF15 expression levels for AKI.Results The levels of respiratory rate,heart rate,glucose,creatinine,lactate,along with the proportion of infection originating from an intra-abdominal source,in the study group were higher than those in the control group,while the levels of oxygen saturation,albumin,hemoglobin,platelet count,and mean arterial pressure(MAP)were lower(P<0.05).The expression levels of TLR9 and GDF15 in the study group were higher than those in the control group(P<0.05).Spearman correlation analysis showed that the expression levels of TLR9 and GDF15 were positively correlated with the occurrence of AKI(r=0.587,0.621,both P<0.05).lactate(OR=2.309,95%CI:1.184-4.506),MAP(OR=2.155,95%CI:1.066-4.356),creatinine(OR=2.077,95%CI:1.014-4.256),TLR9(OR=2.606,95%CI:1.471-4.620),and GDF15(OR=2.492,95%CI:1.437-4.322)were identified as independent risk factors for AKI in sepsis patients(P<0.05).The area under the curve of TLR9,GDF15,and their combination for predicting sepsis-associated AKI were 0.812,0.759,and 0.813,respectively.Conclusion The expression levels of TLR9 and GDF15 are closely associated with the occurrence of sepsis-associated AKI and may serve as predictive indicators for sepsis-associated AKI.关键词
脓毒症/Toll样受体9/生长分化因子15/急性肾损伤Key words
sepsis/Toll-like receptor 9/growth differentiation factor 15/acute kidney injury引用本文复制引用
邢斌瑜,申存毅,林婷,谭文君..脓毒症患者TLR9、GDF15表达水平及与急性肾损伤发生的关系[J].转化医学杂志,2026,15(1):1-5,5.基金项目
陕西省重点研发计划项目(2023-YBSF-421) （2023-YBSF-421）
