转化医学杂志2026，Vol.15Issue(1)：11-14,4.DOI:10.3639/j.issn.2095-3097.2026.01.003
外周血抗米勒管激素和甲状腺特异性抗体检测对多囊卵巢综合征患者妊娠结局的预测价值
Predictive Value of Peripheral Blood Anti-Müllerian Hormone and Thyroid Specific Antibodies for Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome
摘要
Abstract
Objective To explore the predictive value of peripheral blood anti-Müllerian hormone(AMH)and thyroid-specific antibody levels on pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods A total of 120 patients with PCOS admitted to Jiangjin District Maternal and Child Health Hospital of Chongqing from January 2022 to January 2024 were included for retrospective analysis.All patients underwent detection of peripheral blood AMH,thyroid-stimulating hormone(TSH),and thyroid-specific antibodies[thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)].According to pregnancy outcomes,patients were divided into a pregnancy group(73 cases)and a non-pregnancy group(47 cases).The levels of peripheral blood AMH,TSH,TPOAb,and TGAb were compared between the two groups.The pregnant patients were followed up and further divided into a good pregnancy outcome group(44 cases)and a poor pregnancy outcome group(29 cases)based on their pregnancy outcomes.The predictive value of peripheral blood AMH,TSH,and thyroid-specific antibody levels on pregnancy outcomes and their influence on pregnancy outcomes were analyzed.Results The levels of AMH,TPOAb,and TGAb in the non-pregnancy group were higher than those in the pregnancy group(P<0.05).The levels of AMH,TPOAb,and TGAb in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).The area under the curve(AUC)of the combination of AMH,TPOAb,and TGAb for predicting pregnancy outcomes in PCOS patients was greater than that of each indicator alone(P<0.05).The proportions of patients with pre-pregnancy BMI≥25.00 kg/m²,gestational hypertension,gestational diabetes mellitus,AMH≥7.07 ng/mL,TPOAb≥70.89 IU/mL,and TGAb≥58.88 IU/mL in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).Gestational hypertension,gestational diabetes mellitus,AMH≥7.07 ng/mL,TPOAb≥70.89 IU/mL,and TGAb≥58.88 IU/mL were identified as independent influencing factors for pregnancy outcomes in PCOS patients(P<0.05).Conclusion Abnormally elevated levels of peripheral blood AMH,TPOAb,and TGAb are independent influencing factors for poor pregnancy outcomes in PCOS patients,and the combined detection of these indicators has good predictive value for pregnancy outcomes.关键词
多囊卵巢综合征/抗米勒管激素/甲状腺特异性抗体/妊娠结局/预测价值Key words
polycystic ovary syndrome/Anti-Müllerian Hormone/thyroid specific antibodies/pregnancy outcomes/predictive value引用本文复制引用
兰波,明露敏,张瑞伶,王燕,兰瑞伦,刘进..外周血抗米勒管激素和甲状腺特异性抗体检测对多囊卵巢综合征患者妊娠结局的预测价值[J].转化医学杂志,2026,15(1):11-14,4.基金项目
重庆市卫生健康委妇幼科研培育项目(2021FY113) （2021FY113）
