转化医学杂志2026，Vol.15Issue(1)：25-29,5.DOI:10.3639/j.issn.2095-3097.2026.01.006
自发性乳糜疾病患者PROX1、FOXC2和VEGFR3基因表达模式的研究
Study on the Expression Patterns of PROX1,FOXC2,and VEGFR3 Genes in Patients with Spontaneous Chylous Disorders
摘要
Abstract
Objective To investigate the correlation between key lymphatic development genes prospero homeobox 1(PROX1),forkhead box protein C2(FOXC2),and vascular endothelial growth factor receptor 3(VEGFR3)in spontaneous chylous disorders.Methods A retrospective study was conducted from January 2019 to December 2023.Twenty-five patients with spontaneous chylous disorders were selected as the patient group,and 20 healthy volunteers undergoing physical examination during the same period were selected as the control group from Shanghai Pudong New Area Punan Hospital.Protein and mRNA expression levels of PROX1,FOXC2,and VEGFR3 in whole blood were compared between the two groups.Results Among the 25 patients with spontaneous chylous disorders,there were 11 cases of chyluria,6 cases of chylous ascites,and 8 cases of chylothorax.No statistically significant difference was found in whole blood protein expression levels of PROX1,FOXC2,and VEGFR3 between the control group and the patient group(P>0.05);However,mRNA expression levels of PROX1,FOXC2,and VEGFR3 were significantly higher in the patient group than in the control group(P<0.05).There were no statistically significant differences in PROX1 and FOXC2 expressions among patients with chyluria,chylothorax and chylous ascites(P>0.05).Conclusion The upregulation of PROX1,FOXC2,and VEGFR3 gene expression in spontaneous chylous diseases suggests that these genes may be involved in the occurrence and development of the disease by affecting lymphatic structure and function.关键词
自发性乳糜疾病/淋巴管病变/前同源盒基因1/叉头框蛋白C2/血管内皮生长因子受体3/基因表达Key words
spontaneous chylous disorders/lymphatic lesions/prospero homeobox 1/forkhead box protein C2/vascular endothelial growth factor receptor 3/gene expression引用本文复制引用
俞家顺,吕向国,周燕峰,夏维木,唐崎,李文敏,郑勇军,郑立传,于澎,李展翅,叶惟靖..自发性乳糜疾病患者PROX1、FOXC2和VEGFR3基因表达模式的研究[J].转化医学杂志,2026,15(1):25-29,5.基金项目
国家自然科学基金(82270707) （82270707）
浦东新区卫生健康委员会学科建设计划项目(PWZzb2022-07) （PWZzb2022-07）
浦东新区卫生健康委员会学科带头人人才计划项目(PWRd2022-07) （PWRd2022-07）
浦东新区科技发展基金事业单位民生科研专项医疗项目(PKJ2025-Y30) （PKJ2025-Y30）
