转化医学杂志2026，Vol.15Issue(1)：36-40,5.DOI:10.3639/j.issn.2095-3097.2026.01.008
D-二聚体与血小板比值对老年COPD患者发生静脉血栓栓塞的预测价值
Predictive Value of the D-Dimer to Platelet Ratio for Venous Thromboembolism in Elderly Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To explore the predictive value of the D-dimer to platelet ratio(DPR)for venous thromboembolism(VTE)in elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 150 elderly patients with COPD admitted to Sichuan Xiandai Hospital from January 2023 to September 2025 were selected and divided into two groups based on the occurrence of VTE:the VTE group(36 cases)and the non-VTE group(114 cases).The general clinical data of the two groups were compared;multivariate logistic stepwise regression analysis was used to identify the influencing factors for VTE in elderly COPD patients;and receiver operating characteristic curve analysis was applied to evaluate the predictive value of DPR for VTE in elderly COPD patients.Results In the VTE group,age,bed rest duration≥7 days,fibrinogen,D-dimer,and DPR were higher than those in the non-VTE group,while forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC),oxygen saturation,and platelet count were lower than those in the non-VTE group(all P<0.05).Multivariate logistic stepwise regression analysis showed that bed rest duration≥7 days(OR=3.501,95%CI:1.595-7.683),elevated fibrinogen(OR=2.776,95%CI:1.392-5.534),and DPR≥0.62×10-2(OR=3.059,95%CI:1.502-6.231)were independent risk factors for VTE in elderly COPD patients,while a higher FEV1/FVC(OR=0.510,95%CI:0.321-0.809)was an independent protective factor(all P<0.05).The area under the curve(AUC)of DPR for predicting VTE in elderly COPD patients was 0.912,which was significantly superior to the AUC of D-dimer(0.779)and platelet count(0.863)alone(Z=9.362,8.025;both P<0.001).Conclusion Elevated DPR is closely related to the occurrence of VTE in elderly COPD patients and has good predictive value.关键词
D-二聚体/血小板比值/老年/慢性阻塞性肺疾病/静脉血栓栓塞Key words
D-dimer to platelet ratio/elderly/chronic obstructive pulmonary disease/venous thromboembolism引用本文复制引用
杨政,李玲春,汤发艳,陈静..D-二聚体与血小板比值对老年COPD患者发生静脉血栓栓塞的预测价值[J].转化医学杂志,2026,15(1):36-40,5.基金项目
成都市卫生健康委员会课题项目(2024492) （2024492）
