浙江大学学报（医学版）2025，Vol.54Issue(6)：707-717,11.DOI:10.3724/zdxbyxb-2025-0138
乳腺癌患者生育管理现状和研究前沿
Fertility management in breast cancer patients:current strategies and research advances
摘要
Abstract
Breast cancer patients in China tend to be diagnosed at a younger age,making fertility issues a significant clinical and societal challenge.Current evidence indicates that the fertility rate among breast cancer survivors is substantially lower than that of the general population of the same age.Both the disease itself and antitumor treatments—including chemotherapy,radiotherapy,endocrine therapy,targeted therapy,and immunotherapy—can adversely affect female fertility.Therefore,fertility considera-tions should be integrated into the comprehensive management of breast cancer from the time of diagnosis.Several guidelines and consensus statements have been established to direct fertility management in breast cancer patients.Clinical practice has achieved some success in fertility preservation through pharmacological,surgical,and assisted reproductive technologies,which help to mitigate treatment-related damage to fertility.Nevertheless,further progress relies on multidisciplinary collaboration,particularly in addressing the ethical and legal aspects of fertility preservation.Recent advances in research on hereditary breast cancer,risk assessment,and preimplantation genetic testing for polygenic diseases offer new perspectives and directions for fertility management in breast cancer patients.This review systematically summarizes the current fertility status,existing management strategies,and cutting-edge research related to healthy reproduction in breast cancer patients,with the aim of supporting the standardization of fertility management protocols.关键词
乳腺癌/生育管理/生育力保存/生殖伦理学/植入前遗传学检测/综述Key words
Breast cancer/Fertility management/Fertility preservation/Reproductive ethics/Preimplantation genetic testing/Review分类
医药卫生引用本文复制引用
周娇娇,金敏,黄荷凤..乳腺癌患者生育管理现状和研究前沿[J].浙江大学学报（医学版）,2025,54(6):707-717,11.基金项目
国家自然科学基金(82172344,82372866)This study was supported by National Natural Science Foundation of China(82172344,82372866) （82172344,82372866）
