浙江大学学报（医学版）2025，Vol.54Issue(6)：754-763,10.DOI:10.3724/zdxbyxb-2025-0148
干细胞治疗早发性卵巢功能不全临床研究进展
Stem cell therapy for premature ovarian insufficiency:a review of clinical evidence and therapeutic strategies
摘要
Abstract
Premature ovarian insufficiency(POI),characterized by the decline of ovarian function before age 40,significantly compromises fertility and long-term health of patients.Stem cell therapy has emerged as a promising approach for POI.This review synthesizes clinical evidence from studies utilizing cells sourced from adult tissues(e.g.,adipose-derived mesenchymal stem cells,bone marrow mesenchymal stem cells and peripheral blood stem cells)as well as from perinatal tissues(e.g.,human amniotic epithelial cells and umbilical cord-derived mesenchymal stem cells).Evidence suggests that stem cell transplantation can improve ovarian reserve,reflected by reduced follicle-stimulating hormone levels and increased estradiol and anti-Müllerian hormone levels,with some patients resuming menstruation and achieving pregnancy.However,treatment efficacy is influenced by patient-specific factors and clinical protocols.Optimizing stem cell transplantation protocols is pivotal for enhancing the clinical efficacy and safety.This article elaborates on key optimization strategies,including transplantation timing,delivery routes,and combination therapies,proposing that early intervention and person-alized regimens may improve outcomes.We also discuss patient benefits(such as pregnancy outcomes and quality of life)as well as treatment safety,and explore the clinical value of stem cell therapy for POI.Future research should focus on refining personalized strategies,investigating the therapeutic potential of stem cell-derived agents,and establishing long-term follow-up,thereby advancing POI therapy toward precision medicine and standardized application.关键词
早发性卵巢功能不全/卵巢早衰/间充质干细胞/干细胞移植/临床试验/安全性/治疗效果/综述Key words
Premature ovarian insufficiency/Premature ovarian failure/Mesenchymal stem cell/Stem cell transplantation/Clinical trial/Safety/Therapeutic effect/Review分类
医药卫生引用本文复制引用
成子昕,赖东梅..干细胞治疗早发性卵巢功能不全临床研究进展[J].浙江大学学报（医学版）,2025,54(6):754-763,10.基金项目
上海市细胞治疗临床医学研究中心(23J41900100) （23J41900100）
国家自然科学基金(82271664) （82271664）
上海市卫生健康委员会科研项目(202240343)The study was supported by Shanghai Clinical Research Center for Cell Therapy(23J41900100),National Natural Science Foundation of China(82271664),and Scientific Research Program of Shanghai Municipal Health Commission(202240343) （202240343）
