浙江大学学报（医学版）2025，Vol.54Issue(6)：764-771,8.DOI:10.3724/zdxbyxb-2025-0480
初级纤毛对生育力的影响研究进展
Research progress on the roles of primary cilia in fertility
摘要
Abstract
Primary cilia are microtubule-based organelles that project from the cell surface.They are present in cells from single-celled eukaryotes to vertebrates,including humans.Recent studies have found that primary cilia are also widely distributed in multiple organs and tissues of the reproductive system,where they influence reproductive function by directly participating in or indirectly regulating related signaling pathways,thereby affecting fertility.Primary cilia participate in the regulation of oocyte meiosis and development.They also influence sperm maturation by regulating the homeostatic microenvironment required for spermiogenesis.By mediating Hedgehog(Hh)and Wnt signaling pathways,primary cilia regulate endometrial receptivity and decidual response,thereby influencing the embryo implantation rate.Furthermore,primary cilia control migration,invasion,differentiation,and vascular remodeling of human chorionic villi mesenchymal stromal cells and trophoblasts.Structural or functional impairment of primary cilia may disrupt placental vascular remodeling,leading to placental hypoplasia,potentially through the downregulation of downstream target genes of the Hh signaling pathway.Moreover,primary cilia may be involved in ovarian aging,ovulation,and endocrine function.This article reviews the research progress on the relationship between primary cilia and fertility,explores the potential mechanisms underlying the roles of primary cilia in gamete development,endometrial receptivity,decidualization,placental development,and ovarian reproductive endocrine function,aiming to provide new insights for fertility preservation and the prevention and treatment of human reproductive disorders.关键词
初级纤毛/生育力/卵子/精子/子宫内膜/胎盘发育/卵巢功能/综述Key words
Primary cilium/Fertility/Egg/Sperm/Endometrium/Placental development/Ovarian function/Review分类
医药卫生引用本文复制引用
袁圆,刘睿,黄荷凤..初级纤毛对生育力的影响研究进展[J].浙江大学学报（医学版）,2025,54(6):764-771,8.基金项目
浙江省"尖兵领雁+X"科技计划(2025C02121)This study was supported by"Pioneer"and"Leading Goose"R&D Program of Zhejiang(2025C02121) （2025C02121）
