浙江大学学报（医学版）2025，Vol.54Issue(6)：772-784,13.DOI:10.3724/zdxbyxb-2025-0085
细胞外囊泡在早期胚胎发育中的作用及应用于辅助生殖技术
The role of extracellular vesicles in early embryo development and their application in assisted reproductive technologies
摘要
Abstract
Extracellular vesicles(EVs)are membrane-bound vesicles secreted by cells,including exosomes,microvesicles,and apoptotic bodies,which play critical roles in intercellular communication,material transport,and signal transduction.In recent years,increasing evidence has highlighted the essential function of EVs in early embryo development.By carrying bioactive molecules such as proteins,nucleic acids(e.g.,mRNA and miRNA),and lipids,EVs regulate embryonic gene expression,cell proliferation,differ-entiation,and the microenvironment.Studies have shown that EVs derived from various segments of the female reproductive tract can enhance embryonic developmental potential,improve embryo quality,and facilitate implantation.Additionally,EVs secreted by embryos themselves participate in intercellular communication and play pivotal roles during embryogenesis.This review summarizes recent advances in understanding the functions of EVs in early embryo development,discusses their roles in mediating cell-to-cell com-munication and regulating gene expression,and explores the potential applications in reproductive medicine and clinical practice,offering new perspectives for optimizing assisted reproductive technologies.关键词
细胞外囊泡/早期胚胎发育/微RNA/信号转导/辅助生殖技术/综述Key words
Extracellular vesicles/Early embryo development/MicroRNA/Signal transduction/Assisted reproduction technology/Review分类
医药卫生引用本文复制引用
王海潮,李晓璇,蓝红燕,童晓嵋..细胞外囊泡在早期胚胎发育中的作用及应用于辅助生殖技术[J].浙江大学学报（医学版）,2025,54(6):772-784,13.基金项目
浙江省"尖兵""领雁"研发攻关计划(2023C03034)This study was supported by"Pioneer"and"Leading Goose"R&D Program of Zhejiang(2023C03034) （2023C03034）
