针灸临床杂志2025，Vol.41Issue(12)：1-6,6.DOI:10.19917/j.cnki.1005-0779.025228
基于静息态功能磁共振成像探讨针刺干预轻度认知障碍的研究探析
Research Exploration on Acupuncture Intervention for MCI Based on Resting-State fMRI
摘要
Abstract
Mild cognitive impairment(MCI),as a prodromal manifestation of Alzheimer's disease,not only impairs patients' ability to perform daily activities and adapt socially but also imposes a heavy burden on families.Currently,there is no effective pharmacological treatment for MCI.In recent years,acupuncture has been shown to improve cognitive function,although its mechanisms of action remain complex.Functional magnetic resonance imaging(fMRI),with its ability to accurately localize abnormal cognitive brain regions,provides valuable visual evidence to support the central mechanisms underlying acupuncture treatment for MCI.This review summarizes the current research on resting-state fMRI studies of acupuncture in the treatment of MCI,focusing on two key aspects:functional segregation(local spontaneous brain activity)and functional integration(functional connectivity of brain networks).Based on the current literature,this study discusses existing challenges and provides perspectives for future study designs,addressing key factors such as subject selection,acupuncture intervention protocols,MRI scanning parameters,and data analysis methods.关键词
轻度认知障碍/针刺疗法/静息态功能磁共振成像/中枢机制Key words
Mild cognitive impairment/Acupuncture therapy/fMRI/Central mechanism分类
医药卫生引用本文复制引用
刘月,王东岩,董旭,周以皓,杨俊驰,张莹..基于静息态功能磁共振成像探讨针刺干预轻度认知障碍的研究探析[J].针灸临床杂志,2025,41(12):1-6,6.基金项目
国家自然科学基金面上项目,编号:82374601 （）
黑龙江中医药大学创新团队建设项目,编号:2017sit01. （）
