针灸临床杂志2025，Vol.41Issue(12)：14-19,6.DOI:10.19917/j.cnki.1005-0779.025230
基于定量脑电图探讨调神定志养脑法治疗卒中后认知障碍的临床研究
Clinical Study on Treatment of Post-Stroke Cognitive Impairment by Tiaoshen Dingzhi Yangnao Method Based on qEEG
摘要
Abstract
Objective:To observe the curative effect of Tiaoshen Dingzhi Yangnao method in treatment of post-stroke cognitive impairment(PSCI),and to explore its underlying mechanism based on quantitative electroencephalography(qEEG).Methods:A total of 61 patients meeting the inclusion criteria were randomly assigned to the trial group(n=31)and the control group(n=30).The control group received Donepezil Hydrochloride Tablet combined with cognitive rehabilitation training;on which basis,the trial group also received Tiaoshen Dingzhi Yangnao needling Shangxing(DU23),Wuchu(GB13),Shenting(DU24),Meichong(BL3),and Quchai(BL4),combined with compound manual manipulations.Both groups underwent treatment for 8 weeks.The scales of MoCA and ADL,blood biomarkers Hcy and ESR,and EEG power spectrum analysis were evaluated before and after 8 weeks of treatment in the two groups.Results:After 8 weeks of treatment,MoCA scores in both groups increased significantly compared with baseline(P＜0.05),and the post-treatment difference between the two groups was also statistically significant(P＜0.05).ADL scores in both groups decreased significantly after treatment compared with baseline(P＜0.05),with a significant difference between the groups(P＜0.05).Serum levels of Hcy and ESR in both groups were significantly reduced after 8 weeks of treatment compared with baseline(P＜0.05),and intergroup comparisons after treatment showed significant differences(P＜0.05).In the trial group,whole-brain αRP and βRP increased significantly after treatment compared with baseline(P＜0.05),and post-treatment intergroup comparisons also showed significant differences(P＜0.05).Conversely,whole-brain θRP,δRP,and DTABR in the trial group decreased significantly after treatment compared with baseline(P＜0.05),with significant intergroup differences observed post-treatment(P＜0.05).Conclusion:Tiaoshen Dingzhi Yangnao method combined with standard treatment,may improve cognitive function and activities of daily living in patients with PSCI,possibly through modulating the slowing of whole-brain oscillatory activity.关键词
卒中/认知障碍/针灸/调神定志养脑法/定量脑电图Key words
Stroke/Cognitive impairment/Acupuncture/Tiaoshen Dingzhi Yangnao method/Quantitative electroencephalography分类
医药卫生引用本文复制引用
栾逸先,赵东,梁嫄,王雪晴,程为平,孙忠人,纪青灼..基于定量脑电图探讨调神定志养脑法治疗卒中后认知障碍的临床研究[J].针灸临床杂志,2025,41(12):14-19,6.基金项目
国家中医药管理局中医药循证项目,编号:2019XZZX-ZJ005 （）
海南省"南海新星"医疗卫生人才平台项目,编号:NHXX-WJW-2023018 （）
山东省中医药科技项目,编号:M20240214 （）
青岛市医疗卫生科研项目,编号:2025-WJKY028. （）
