中外医学研究2026，Vol.24Issue(1)：5-8,4.DOI:10.14033/j.cnki.cfmr.2026.01.002
新生儿坏死性小肠结肠炎肠造瘘术后肠道菌群结构及功能改变对婴幼儿体格生长发育的影响
Impact of Changes in Gut Microbiota Structure and Function on the Physical Growth and Development of Infants and Young Children After Enterostomy for Neonatal Necrotizing Enterocolitis
摘要
Abstract
Objective:To explore the influence of changes in the structure and function of intestinal flora after enterostomy for neonatal necrotizing enterocolitis(NEC)on the physical growth and development of infants and young children.Method:22 children with neonatal necrotizing enterocolitis(NEC)after enterostomy admitted to Shenzhen Children's Hospital were selected as the observation group,and 22 healthy infants and young children during the same period were selected as the control group.Fecal samples were collected at multiple time points,and 16S ribosomal RNA(16S rRNA)sequencing was performed to analyze the intestinal flora.Growth and development indicators were recorded simultaneously to analyze the relationship between the characteristics of the flora and growth and development.Result:The diversity index of intestinal flora in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Six months after fistula closure,the microbiota structure in the observation group gradually recovered.Compared with the control group,the difference was statistically significant(P<0.05).The functional analysis of the intestinal flora in the observation group showed that the expression of genes related to carbohydrate metabolism decreased,and the difference was statistically significant(P<0.01).The structural changes of the microbiota were positively correlated with the body mass index(BMI)(r=0.726,P<0.01).Conclusion:The recovery after fistula closure is slow.The changes in the structure and function of the microbiota are closely related to delayed physical growth and development.The growth and development of children can be improved by regulating the intestinal microbiota.关键词
新生儿坏死性小肠结肠炎/肠造瘘术/肠道菌群/体格生长发育/16S核糖体RNA测序Key words
Necrotizing enterocolitis/Enterostomy/Gut microbiota/Growth/16S rRNA引用本文复制引用
邹沙芹,周桂芬,文静,刘丹,郝玉田,张晓旭..新生儿坏死性小肠结肠炎肠造瘘术后肠道菌群结构及功能改变对婴幼儿体格生长发育的影响[J].中外医学研究,2026,24(1):5-8,4.基金项目
深圳市儿童医院护理临床研究专项项目(HLLCYJ2022017) （HLLCYJ2022017）
