中医药信息2026，Vol.43Issue(2)：39-46,8.DOI:10.19656/j.cnki.1002-2406.20260207
基于血清药物化学和网络药理学探讨槐花散治疗溃疡性结肠炎的作用机制
Study on the Mechanism of Huaihua Powder in the Treatment of Ulcerative Colitis Based on Serum Pharmacochemistry and Network Pharmacology
摘要
Abstract
Objective To explore the mechanism of Huaihua Powder in the treatment of ulcerative colitis(UC)on the basis of serum pharmacochemistry combined with network pharmacology and molecular docking technology.Methods UPLC-Q-TOF-MS was used to analyze and identify the blood components of Huaihua Powder in the drug-containing serum of rats.The network pharmacology method was employed to predict the key active ingredients,core targets and potential pathways of Huaihua Powder in the treatment of UC.Molecular docking technology was used to preliminarily verify the affinity of the core targets and key active ingredients obtained by the mechanism of action.Results 11 prototype blood components and 13 metabolites were identified in the drug-containing serum of rats.A total of 206 drug-disease intersection targets were identified by the network pharmacology approach,with the core targets being IL6,AKT1,TNF,EGFR and STAT3.The key active ingredients are Yanagawa ichthyocin,neohesperidin and geranidin.The core targets exerted synergistic effects by regulating PI3K/Akt,IL-17,PPAR and other pathways.The molecular docking results showed that the predicted 5 core targets and 3 key active ingredients had strong affinity.Conclusion This study provides a reference for the elucidation of the mechanism of Huaihua Powder in the treatment of ulcerative colitis.Combined application of serum medicinal chemistry with network pharmacology reveals the synergistic mechanism of"multi-component,multi-target,and multi-pathway"of the drug.关键词
槐花散/溃疡性结肠炎/血清药物化学/网络药理学/分子对接Key words
Huaihua Powder/Ulcerative colitis/Serum pharmacochemistry/Network pharmacology/Molecular docking引用本文复制引用
张明慧,王帅,李天娇,郑莹,赵琳,包永睿,孟宪生..基于血清药物化学和网络药理学探讨槐花散治疗溃疡性结肠炎的作用机制[J].中医药信息,2026,43(2):39-46,8.基金项目
辽宁省自然科学基金计划博士科研启动项目(2025-BS-0728) （2025-BS-0728）
辽宁省教育厅基本科研项目(JYTQN2023474) （JYTQN2023474）
