中医药信息2026，Vol.43Issue(2)：53-59,7.DOI:10.19656/j.cnki.1002-2406.20260209
基于因子与聚类分析的多囊卵巢综合征中医证候分布规律研究
Study on Distribution Patterns of TCM Syndromes in Polycystic Ovary Syndrome Based on Factor and Cluster Analyses
摘要
Abstract
Objective To analyze the distribution patterns of traditional Chinese medicine(TCM)syndromes in polycystic ovary syndrome(PCOS)based on multicenter large-scale data and establish a pathogenic classification framework to provide a basis for precise clinical differentiation.Methods A multicenter cross-sectional study design was employed,enrolling 936 PCOS patients from seven Tertiary A hospitals.A standardized TCM syndrome questionnaire was designed through literature mining and Delphi expert consultation.Frequency analysis was used to extract core symptoms,factor analysis to identify syndrome elements,and core syndrome patterns were summarized by the K-means clustering algorithm.Results High-frequency symptoms predominantly included soreness and weakness of waist and knees,oily skin,depressive mood with frequent sighing,and acne.The primary pathogenesis location factors were identified as the kidney,lung/large intestine,and thoroughfare vessel,with damp-heat,blood stasis,and yin deficiency as the key pathogenesis nature factors.Cluster analysis identified five major syndrome patterns:kidney yin deficiency with damp-heat,spleen deficiency with phlegm-dampness,qi stagnation with blood stasis,dampness-heat and blood stasis obstructing,and kidney yang deficiency with phlegm-dampness,covering 97.86%of cases.Conclusion This study established five core PCOS syndrome patterns dominated by kidney yin deficiency with damp-heat,spleen deficiency with phlegm-dampness,qi stagnation with blood stasis,dampness-heat and blood stasis obstructing,and kidney yang deficiency with phlegm-dampness,providing data support for syndrome standardization.Meanwhile,the pathogenic significance of disease-location elements"thoroughfare vessel"and"lung/large intestine"in PCOS pathogenesis should to be taken seriously.关键词
多囊卵巢综合征/中医证候/病机/冲脉逆盛/因子分析/聚类分析Key words
Polycystic ovary syndrome/TCM syndrome/Pathogenesis/Reversal and excess of thoroughfare vessel/Factor analysis/Cluster analysis引用本文复制引用
戴金芳,俞康,李温珏,卢君,钟素琴,梁瑞宁..基于因子与聚类分析的多囊卵巢综合征中医证候分布规律研究[J].中医药信息,2026,43(2):53-59,7.基金项目
国家自然科学基金项目(82060880,81860865,81560783) （82060880,81860865,81560783）
江西省重点研发计划"揭榜挂帅"项目(20223BBG7101) （20223BBG7101）
江西省中医妇产科疾病临床医学研究中心基金项目(20181BCG42003) （20181BCG42003）
江西省中医生殖内分泌疾病临床研究基地建设项目(赣中医药科教字[2020]6号) （赣中医药科教字[2020]6号）
梁瑞宁全国名老中医药专家传承工作室(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
江西中医药大学科技创新团队项目(CXTD22013) （CXTD22013）
中医女性生殖健康及相关疾病研究与转化江西省重点实验室项目(2024SSY06311) （2024SSY06311）
