川北医学院学报2026，Vol.41Issue(1)：39-42,4.DOI:10.3969/j.issn.1005-3697.2026.01.008
糠酸莫米松鼻喷雾剂联合卢帕他定治疗变应性鼻炎的疗效及对患者血清炎症相关指标的影响
Efficacy of mometasone furoate nasal spray combined with rupatadine in the treatment of allergic rhinitis and their effects on serum inflammation related indicators
摘要
Abstract
Objective:To explore the therapeutic efficacy of combining rupatadine tablets with mometasone furoate nasal spray in the treatment of allergic rhinitis(AR)and its effect on serum inflammation related indicators.Methods:A total of 118 AR patients were enrolled.The patients were divided into two groups according to different treatment regimens:a control group(n=59)or an observation group(n=59).The control group received mometasone furoate nasal spray alone,while the observation group received both mometasone furoate nasal spray and rupatadine tablets.Treatment duration was 4 weeks for both groups.Before and after treatment,nasal symptom scores(TNSS),total nasal accompanying symptom scale(TNNSS),and the rhinoconjunctivitis quality of life questionnaire(RQLQ)were assessed.Serum levels of immunoglobulin E(IgE),interleukin(IL)-4,IL-6,and IL-10,as well as peripheral blood eosinophil(EOS)counts,were measured.Results:The total effectiveness rate was higher in the observation group(96.61%)compared to the control group(83.05%)(P<0.05).After treatment,TNSS,TNNSS,and RQLQ scores were lower in the observation group than in the control group(P<0.05).Serum IgE,EOS counts,and IL-4 and IL-6 levels were also lower in the observation group(P<0.05),while IL-10 levels were higher(P<0.05).Conclusion:The combination of rupatadine tablets and mometasone furoate nasal spray alleviates nasal symptoms,reduces IgE and EOS levels,mitigates inflammatory responses,and enhances therapeutic outcomes in AR patients.关键词
变应性鼻炎/糠酸莫米松/卢帕他定/免疫球蛋白E/炎症反应Key words
Allergic rhinitis/Mometasone furoate/Rupatadine/Immunoglobulin E/Inflammatory response分类
医药卫生引用本文复制引用
马莹,杨宇,张静..糠酸莫米松鼻喷雾剂联合卢帕他定治疗变应性鼻炎的疗效及对患者血清炎症相关指标的影响[J].川北医学院学报,2026,41(1):39-42,4.基金项目
四川省自然科学基金项目(2023NSFSC1449) （2023NSFSC1449）
