川北医学院学报2026，Vol.41Issue(1)：43-46,4.DOI:10.3969/j.issn.1005-3697.2026.01.009
血清SF、CRP、D-D水平与儿童难治性肺炎支原体肺炎的关系
Relationship of serum SF,CRP and D-D levels with refractory Mycoplasma pneumoniae pneumonia in children
摘要
Abstract
Objective:To evaluate the early predictive value of serum ferritin(SF),C-reactive protein(CRP)and D-dimer(D-D)on children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods:A total of 107 children with Mycoplasma pneumoniae pneumonia(MPP)were selected and classified into general group(GMPP group,n=51)and refractory group(RMPP group,n=56)according to treatment response and disease progression.The differences in serum SF,CRP and D-D levels in acute phase were compared between groups.Logistic regression analysis was adopted to screen the influencing factors of RMPP.Receiver operating characteristic(ROC)curve was utilized to evaluate the predictive efficiency of serum SF,CRP,D-D and combined detection of the three indicators on RMPP.Results:There was no statistically significant difference in general information such as age,gender,and admission time between the two groups(P>0.05).The RMPP group had a longer duration of fever and more involvement of lung lobes(P<0.05).The levels of serum SF,CRP and D-D in the RMPP group were higher than those in the GMPP group(P<0.05).Multivariate Logistic regression revealed that the increases of SF,CRP and D-D were the influencing factors of RMPP occurrence(P<0.05).ROC curve analysis suggested that the area under the ROC curve(AUC)of combination of SF,CRP and D-D in predicting RMPP was 0.849,which was better than that of single indicator(P<0.05).Conclusion:Serum SF,CRP and D-D levels are closely related to the disease severity and refractory progression of children with MPP.The three levels can be used as independent predictors of RMPP.Combined detection can provide an important basis for early warning of RMPP in children.关键词
难治性肺炎支原体肺炎/儿童/铁蛋白/C反应蛋白/D-二聚体Key words
Refractory Mycoplasma pneumoniae pneumonia/Children/Ferritin/C-reactive protein/D-dimer分类
医药卫生引用本文复制引用
孙世心,国春柘,王晓雪..血清SF、CRP、D-D水平与儿童难治性肺炎支原体肺炎的关系[J].川北医学院学报,2026,41(1):43-46,4.基金项目
河北省自然科学基金青年科学基金项目(H2021108003) （H2021108003）
河北省邢台市科技局项目(2022ZC127) （2022ZC127）
