川北医学院学报2026，Vol.41Issue(1)：52-56,5.DOI:10.3969/j.issn.1005-3697.2026.01.011
自体乳糜脂肪移植治疗早期增生性瘢痕致关节功能障碍的疗效
Efficacy analysis of autologous emulsified fat grafting in the treatment of early proliferative scarring causing joint dysfunction
摘要
Abstract
Objective:To explore the efficacy of autologous emulsified fat grafting in the treatment of early proliferative scarring leading to joint dysfunction.Methods:84 patients with early proliferative scarring leading to joint dysfunction were included in the prospective study,and were divided into the control group(n=42)and the treatment group(n=42)according to different treatment methods.The control group was treated with conventional scar surface topical application of scarin,and the treatment group was treated with intra-proliferative scar injection of autologous adipose tissue.Both groups were followed up for 2 months.The efficacy,scar condition[Vancouver Scar Scale(VSS),Patient and Observer Scar Assessment Scale(POSAS)scores],joint function recovery,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)],scar index,scar hardness,thickness,width,pathological indicators of scar tissue[fibroblast density,collagen fiber surface density,type I collagen,type III collagen],and the occurrence of complications between two groups were recorded and compared.Results:The treatment group showed higher effective treatment rates and excellent joint function recovery rates compared to the control group(P<0.05).After treatment,the treatment group showed lower VSS,POSAS scores,TNF-α,IL-6 and IL-8 levels,scar index,scar hardness,thickness,width,fibroblast cell density,collagen fiber surface density,type I collagen,and type III collagen levels compared to the control group(P<0.05).There was no significant difference in the rate of complications between the two groups of patients compared to each other(P>0.05).Conclusion:The efficacy of using intra-proliferative scar injection of autologous adipose tissue for the treatment of early proliferative scarring resulting in joint dysfunction is precise,which helps to reduce the inflammatory response,improve the degree of scarring,inhibit scar proliferation,improve the aesthetic effect,and facilitate the promotion of joint function recovery.关键词
乳糜脂肪/增生性瘢痕/关节功能障碍/疗效Key words
Emulsified fat/Proliferative scarring/Joint dysfunction/Efficacy分类
医药卫生引用本文复制引用
邓兴旺,齐旭辉,庞文晶,杨绍贤,张龙,罗菁,韩艳阳..自体乳糜脂肪移植治疗早期增生性瘢痕致关节功能障碍的疗效[J].川北医学院学报,2026,41(1):52-56,5.基金项目
宁夏回族自治区卫生健康系统科研课题(2023-NWKYT-029) （2023-NWKYT-029）
