磁共振成像2026，Vol.17Issue(1)：128-133,6.DOI:10.12015/issn.1674-8034.2026.01.020
多模态结构-功能MRI在孤独症谱系障碍大尺度脑网络层级异常中的研究进展
Research progress on multimodal structural-functional MRI studies of hierarchical large-scale brain network abnormalities in autism spectrum disorder
摘要
Abstract
Autism spectrum disorder(ASD)is a neurodevelopmental condition that emerges in early childhood,characterized by social communication difficulties and restricted,repetitive behaviors.Despite their diverse symptoms,individuals with ASD may have shared neurobiological characteristics.Advances in MRI now allow researchers to study brain network abnormalities in ASD from multiple,noninvasive perspectives.This review highlights recent studies using diffusion and functional MRI,covering tract-based spatial statistics,graph theory analyses,functional gradient mapping,and sliding-window approaches.We focus on how these methods help reveal white matter integrity,functional coordination,and hierarchical brain organization in ASD.We also discuss the potential of multimodal image fusion and artificial intelligence(AI)for ASD subtype identification and auxiliary diagnosis.Overall,findings from multimodal MRI indicate cross-scale alterations of brain networks in ASD,providing new imaging evidence for understanding its neural mechanisms and for supporting early identification and individualized intervention.On this basis,we briefly outline the main limitations of current research and,from an integrated perspective spanning"microstructure-large-scale function-structure-function coupling-multimodal analysis",propose future research directions to inform radiologists and neuroscience researchers.关键词
孤独症谱系障碍/多模态磁共振成像/磁共振成像/大尺度脑网络/结构-功能耦合/机器学习Key words
autism spectrum disorder/multimodal magnetic resonance imaging/magnetic resonance imaging/large-scale brain networks/structure-function coupling/machine learning分类
医药卫生引用本文复制引用
许媛媛,张国敏,伍光榕,方婕,熊思言,杨伟..多模态结构-功能MRI在孤独症谱系障碍大尺度脑网络层级异常中的研究进展[J].磁共振成像,2026,17(1):128-133,6.基金项目
Zunyi City Science and Technology Fund Project[No.Shikehui HZ(2023)491]. 遵义市科学技术基金项目[编号:市科会HZ字(2023)491号] （2023）
