磁共振成像2026，Vol.17Issue(1)：140-145,161,7.DOI:10.12015/issn.1674-8034.2026.01.022
脑类淋巴系统相关中枢神经系统疾病中gBOLD-CSF耦合异常的研究进展
Research progress of abnormal gBOLD-CSF coupling in brain glymphatic system related central nervous system diseases
摘要
Abstract
The glymphatic system(GS)is a waste clearance pathway in the brain,and its impaired function is closely associated with various central nervous system diseases.Resting-state functional magnetic resonance imaging(rs-fMRI)studies have revealed that low-frequency(<0.1 Hz)global blood oxygen level-dependent(gBOLD)signals are coupled with cerebrospinal fluid(CSF)dynamics,a phenomenon that is related to GS function and provides a new direction for uncovering brain glymphatic dysfunction.This review summarizes the key aspects of the GS,the principles of gBOLD-CSF coupling,and its applications in central nervous system diseases.It aims to synthesize research on GS functional changes in a range of central nervous system disorders,and to clarify the value and prospects of abnormal gBOLD-CSF coupling for assessing disease severity and evaluating treatment efficacy.Meanwhile,this review identifies the limitations of current research and proposes directions for future studies.关键词
中枢神经系统疾病/类淋巴系统/脑脊液/全脑静息态功能磁共振成像信号/磁共振成像Key words
central nervous system diseases/glymphatic system/cerebrospinal fluid/global resting-state functional magnetic resonance imaging signal/magnetic resonance imaging分类
医药卫生引用本文复制引用
苏婧,王祎,安宁宁,杨龙飞,苏琦,张宇彤,张清..脑类淋巴系统相关中枢神经系统疾病中gBOLD-CSF耦合异常的研究进展[J].磁共振成像,2026,17(1):140-145,161,7.基金项目
Liaoning Provincial Department of Education Project in Natural Sciences(No.jyt-dldxfw202006). 辽宁省教育厅自然科学类项目(编号:jyt-dldxfw202006) （No.jyt-dldxfw202006）
